| Project/Area Number |
14571382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | THE UNIVERSITY OF TOKUSHIMA |
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Principal Investigator |
KATOH Shinsuke THE UNIVERSITY OF TOKUSHIMA, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (30243687)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJO Shunji THE UNIVERSITY OF TOKUSHIMA, UNIVERSITY HOSPITAL, LECTURER, 医学部・歯学部附属病院, 助手 (60294683)
SAIRYO Koichi THE UNIVERSITY OF TOKUSHIMA, SCHOOL OF MEDICINE, LECTURER, 医学部, 講師 (10304528)
YASUI Natsuo THE UNIVERSITY OF TOKUSHIMA, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (00157984)
田岡 祐二 徳島大学, 医学部附属病院, 講師 (10325277)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | spinal cord injury / spinal injury / secondary injury / oxidative stress / growth plate |
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| Research Abstract |
Current trend on the strategy to restore spinal cord function after mechanical trauma is cell transplantation, which aims to fill the cavity with neuronal cells. However, mail lost function is the. long-tract function, and transplantation of the neuronal cells alone cannot rebuild the conductivity. In this project, we focused on the restoration of the conductivity by cell transplantation.
To restore the long-tract function, the condition around the mechanical trauma should be improved. We focused on the endothelial injury at the site of the mechanical trauma. We showed that the inhibition of the cycleoxygenase-2 or administration of prostaglandin-E2 improved the hindlimb function of the rat spinal cord injury model. We postulated that the reduction of the oxidative stress is a part of the effect of those drugs.
We also investigated the mechanism of the cervical spinal injuries in children. Children below the age of 8 have a characteristics of lack of apparent fractures in the cervical spine. We showed that the growth plate of the vertebral body is the weakest link against the antero-posterior shear force. The growth plate was demonstrated to be disrupted by the low-energy force if it applied for several days. The strength of the growth plate depended on the skeletal maturity.
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