The mechanism of brain-hypothermic therapy for ischemic brain damage

• Project/Area Number: 14571456
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Sapporo Medical University
• Principal Investigator: MORI Kazuhisa Sapporo Medical University, Assistant professor, 医学部, 講師 (10253999)
• Co-Investigator(Kenkyū-buntansha): ASAI Yasufumi Sapporo Medical University, professor, 医学部, 教授 (80094192) ; HATAMOTI Keisuke Sapporo Medical University, instructor, 医学部, 助手 (20347173) ; NARA Satoshi Sapporo Medical University, instructor, 医学部, 助手 (90253997) ; 浦 英樹 札幌医科大学, 医学部, 講師 (50264510)
• Project Period (FY): 2002 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: apoptosis / Ubipuitin / HSC73 / ORP150 / ischemic brain damage / indication / heat shock protein / 脳低温療法の適応 / 虚血性脳損傷 / HSP / CAI / 熱ストレス蛋白(HSP) / 体外循環回路 / 脳神経保護作用 / 低温循環停止モデル / 低温蘇生モデル

Research Abstract

The purpose of this study is to determine the indications for this therapy by multivariate analysis to determine the characteristics of patients who can expect to benefit from this therapy most. Patients were received either BHT(32-34C,n=36) or brain normothermic therapy (BNT:36-37C,n=18). Data was gathered on multiple event and patient treatment characteristics. The patient outcome was measured by one-month Glasgow outcome scale(GOS). Data was analyzed using univariate and multivariate techniques. Result : Overall 47.2% of patients receiving BHT and 11.2% of BNT patients had a good neurological outcome(p<0.05). Multivariate analysis of patient characteristics revealed relative improvements in patients with an arrest time less than 20min and GCS greater than 5. There were 19 patients in the BHT group who fulfilled these characteristics, and 73.8% of them had a good neurological outcome, which was significant higher than the overall percentage of 47.2%(p<0.05).

Research Products

• [Publications] Kazuhisa Mori: "Indication of brain hypothermia therapy in cardiac arrest"Brain Hypothermia 2004 (Springer-Verlag). (In press). (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Yoshihiro Takeyama: "Brain hypothermic therapy following Cardiopulmonary bypass for cardiac arrest patients who did not respond to advanced cardiovascular life support"Brain Hypothermia 2004 (Springer-Verlag). (In press). (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] 森 和久: "心肺停止患者における脳低温療法の適応と実際"ICUとCCU. 27. 743-750 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kazuhisa Mori: "Indication of brain hypothermia therapy in cardiac arrest"Brain Hypothermia 2004(Springer-Verlag). (in press). (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Yoshihiro Takeyama: "Brain hypothermic therapy following Cardiopulmonary bypass for cardiac arrest patients who did not respond to advanced cardiovascular life support"Brain Hypothermia 2004(Springer-Verlag). (in press). (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kazuhisa Mori: "The brain hypothermia therapy in cardiac Arrest patients"ICU & UUU. 27(8). 743-750 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kazuhisa Mori: "Indication of brain hypothermia therapy in cardiac arrest"Brain Hypothermia 2004 (Springer-Verlag). (In press). (2004)