Effect of inhalational anesthetics for HIF-α mRNA expression in the Septic shock
| Project/Area Number |
14571472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nippon Medical School |
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Principal Investigator |
ONODERA Hidetaka Nippon Medical School, Deppartment of Anesthesiology, assistant, 医学部, 助手 (40328787)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | c-fos / Propofol / midline thalamic nuculei / in situ hybridization / HIF / 低酸素 / LPS / エンドトキシンショック / 出血性ショック |
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| Research Abstract |
We investigate intravenous anesthetic Propofol (2,6-di-isopropylp h enol) suppress the induction of c-fos mRNA in the rat neocortex which expression begin to increase 2 hours before the dark period and remained elevated following the dark period in a normal rat.
Simultaneously, administration of Propofol induce the expression of c-fos mRNA in the midline thalamic nuclei which is also activated by some benzodiazepine narcotic drugs. These indicate that narcotic action of Propofol exhibit via activation of midline thalamic nuclei. We also investigate that c-fos mRNA expression in the olivary nucleus in the medulla and in cereberal cortex in administration of Propofol in the rate of 20mg/kg and 30mg/kg. Rate of 10mg/kg do not induce the c-fos mRNA in these nucleus and cortex suggest that comparative high dose administration of propofol have some affects for these nucleus.
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Report
(3 results)
Research Products
(5 results)
