| Project/Area Number |
14571589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
ISHIZUKA Bunpei St.Marianna University School of Medicine, Department of Obstetrics and Gynecology, Professor, 医学部, 教授 (80097336)
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| Co-Investigator(Kenkyū-buntansha) |
MIMURO Takuhiko St.Marianna University School of Medicine, Department of Ob/Gyn, Instructor, 医学部, 助手 (30308457)
MIMURO Takahisa St.Marianna University School of Medicine, Department of Ob/Gyn, Assistant Professor, 医学部, 講師 (40209854)
ITOH Masanori, t. St.Marianna University School of Medicine, Department of Chemistry, Assistant Professor, 医学部, 講師 (30257349)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | premature ovarian failure / ovary / gene / XO mice / 早期閉経 |
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| Research Abstract |
Premature ovarian failure (POF) is defined as the cessation of menses for > 6 months before the age of 40 years, and affects about % of women (Coulam et al., 1986). It has been suggested that the fragile X mental retardation gene (FMR1) is associated with POF (Uzielli et al., 1999). Two groups have reported that POF occurs at an increased frequency in women carrying the fragile X premutaion (50-200 CGC trinucleotide repeated in the 5' prime untranslated region of the FMR1 gene) (Conway et al., 1998 ; Uzuelli et al., 1999). In this study, we also found that 3 of 62 Japanese patients with POF were carriers of the fragile X premutaion, suggesting the association of the fragile X premutaion and POF. In addition, FMR1 gene product seemed to express in the rat ovary, which suggests that FMR1 gene product may play a role in ovarian function. Furthermore, we are trying to identify other FMR1 gene mutations associating with POF and to determine all nucleotide sequence of FMR1 gene.
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