| Project/Area Number |
14571595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
SUGIYAMA Toru Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (40162903)
|
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| Co-Investigator(Kenkyū-buntansha) |
IZUTSU Toshihiko Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (00103739)
YOSHIZAKI Akira Iwate Medical University, School of Medicine, Lecturer, 医学部, 助手 (40200969)
SHOJI Tadahiro Iwate Medical University, School of Medicine, Research Associate, 医学部, 助手 (00337148)
OTA Shunichiro Kurume University, School of Medicine, Research Associate, 医学部, 助手 (40289476)
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| Project Period (FY) |
2002 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
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| Keywords | Tamoxifen / apoptosis / cell cycle / ovarian cancer / anti-tumor effect / Ovarian Cancer / tamoxifen / rat / Estrogen receptor / estrogen receptor / Rat / Cell cycle |
|---|
| Research Abstract |
The effects of tamoxifen (TAM) on the growth and cell cycle kinetics in an estrogen- and progesterone-receptor negative ovarian cancer in rats were evaluated. Although no macroscopic reducting effect of TAM on tumors was found, proliferation and replacement of connective tissue and the expansion of central necrosis was observed histologically. The administration of TAM (2.0mg/kg) caused a tendency to decrease S-phase cells and increase G0/G1-phase cells. These findings indicate that TAM might inhibit DNA syntheses. TAM significantly increased apoptosis cell in the Sub-G1 region on DNA cytograms in a dose-dependent manner. TAM is therefore thought to have a potentially inhibitory effect on the growth of ovarian cancer.
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