Measurement of impedance in vivo in eye lids-development of examination of malignant lid tumors
| Project/Area Number |
14571675
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kochi University |
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Principal Investigator |
FUKUSHIMA Atsuki (2004) Kochi Universty, medical dwpartment associate, professor, 医学部, 助教授 (40281737)
渡邊 牧夫 (2002-2003) 高知大学, 医学部, 助教授 (00220921)
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| Co-Investigator(Kenkyū-buntansha) |
安藤 元紀 高知大学, 医学部附属病院, 助手 (20222789)
福島 敦樹 高知大学, 医学部附属病院, 助手 (40281737)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | impedance / in vivo / cornea / lid tumor / bullous keratopathy / 生体インピーダンス / 誘電挙動 |
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| Research Abstract |
Dr.Makio Watanabe (head investigator,2002,2003) has investigated measurement of impedance in many types of cells and tissues, and has demonstrated that measurement of impedance in vitro in ocular cells and tissues was possible. Next, he succeeded to measure impedance in vivo of cornea of experimental animals. However, it has not been examined to measure corneal impedance in vivo in humans. Therefore, in this study, we aimed to measure impedance in vivo of ocular tissues in humans. First, after obtaining approval of Kochi Medical School Ethical Committee, we tried to measure corneal impedance in vivo in humans, including healthy volunteers and patients with bullous keratopathy. By using the surface electrode and the impedance analyzer 4194A (Hewlett-Packard) under the control of personal computer, impedance of cornea was measured from 10 KHz to 100 MHz. Data demonstrated that the ratio of the dispersions between low frequency and high frequency differed between healthy volunteers and patients with bullous keratopathy. The ratio was around 1.5 in healthy volunteers, while about 0.5 in patients with bullous keratopathy. Furthermore, we found the trend that a correlation existed between the ratio and the number of corneal endothelial cells. Next, we tried to measure impedance of patients with lid tumor. However, although repeated improvements of the surface electrode, we were not able to measure impedance in vivo of patients with lid tumor.
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Report
(4 results)
Research Products
(4 results)
