| Project/Area Number |
14571705
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
KONDO Satoshi Nagoya City University, Graduate School of Medical Sciences, Assistant Professor, 大学院・医学研究科, 講師 (50234935)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Yoshitaka Nagoya City University, Graduate School of Medical Sciences, Professor and Chair, 大学院・医学研究科, 教授 (40156831)
佐々木 秀文 名古屋市立大学, 大学院・医学研究科, 助手 (00336695)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | neuroblastoma / cDNA microarray / spontaneous differentiation and regression / BioChip(microarray) / 病理組織 / 正常交感神経節 |
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| Research Abstract |
This research planned to fine overexpression gene of neuroblastoma by using Biochip at first. However, technically, because it was impossible, it decided to identify the gene which participates in the mechanism of spontaneous differentiation and regression with cDNA microarray.
Neuroblastoma (NB), one of the most common solid tumors among children, is known found under the age of one year often show spontaneous differentiation and regression. But some shift to unfavorable type and progress to an advance stage with metastasis. Therefore, it is very important to know which tumor will regress or progress. Using histological classified by the degree of maturation, we analyzed gene-expression profiles of 14 NB tumors on coda microarray to elucidate the mechanisms of spontaneous differentiation and regression. Computational analysis identified the gene which has a difference between differentiating NB tumors and poorly differentiated NB tumors. Differentiating NB group included genes associated with cell maturation and apoptosis. Poorly differentiated NB group included in relation to tumorigenesis. The future, examination will be added ; it thinks that we want to be able to lead to development of new therapeutic strategies.
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