| Project/Area Number |
14571741
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
FUJIMURA Akira Iwate Medical University, School of Dentistry, Associate Professor, 歯学部, 助教授 (80173459)
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| Co-Investigator(Kenkyū-buntansha) |
OSAWA Tokuji Iwate Medical University, School of Dentistry, Assistant Professor, 歯学部, 講師 (00103747)
ONODERA Masao Iwate Medical University, School of Dentistry, Researcher, 歯学部, 助手 (10326689)
NOZAKA Yohichiro Iwate Medical University, School of Dentistry, Chief Professor, 歯学部, 教授 (60048379)
NARA Eisuke Iwate Medical University, School of Dentistry, Researcher, 歯学部, 助手 (10275571)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2003: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | lymphatic architecture / head and neck / human / adult / fetus / embryology of lymphatic vessel / lymph node / drug delivery route / リンパ管 / 構築 / 舌 / 腫瘍 / 転移 / 血管新生阻害剤 / TNP-470 |
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| Research Abstract |
The lymphatic architecture in human head and neck regions was studied the relationship with regional lymph node, but not studied about each organs. Therefore, the route between the periphery to the regional lymph node and the connection between the regional lymph nodes were only inferenced. We have studied the lymphatic architecture of each organ in head and neck regions by three-dimensional reconstruction method of serial sections. In this project, we could concern the lymphatic architecture in normal tongue, the dynamics of lymphatic architecture of growth of cancer, and dynamic changes after administration of anti-angiogenic agent. We analogized the metastasis to the regional lymph node starts at the initial lymphatics.
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