| Project/Area Number |
14571905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
SHIIBA Shunji Kyushu Dental College, Associate professor, 歯学部, 助手 (20285472)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Eiji Kyushu Dental College, Associate professor, 歯学部, 助手 (00295859)
NAKANISHI Osamu Kyushu Dental College, Professor, 歯学部, 教授 (50137345)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Neuropathic pain / Interleukin-6 / Inflammatory cytocaine / CCI / Dorsal Root Gangrion / Sciatic nerve / Neuritis / 疼痛関連行動 / 神経因性疼痛 / CCIモデル / 脊髄神経後根神経節 / 坐骨神経 / 神経炎症 / 炎症 / 免疫抑制剤 / 免疫調整剤 / 正弦波電流刺激 |
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| Research Abstract |
It was clear that painful animal model, CFA(complete Freund's adjuvant) and CCI(choronic constriction injury) in sciatic nerve induced neuropathic pain. The pain-related behavior which these models lick hindpow and take escape behavior for heat radiation and a pin prick test. That these pain-related action is inhibited by administration of thalidomide of immunomodulator and cyclosporine S of an immunosuppressive drug, and a substance of inflammatory contributes to neuropathic pain is predicted. Therefore I paid attention to interleukin-6(IL-6) which contributed to neurotization deeply. I understood that a pain-related behavior for all algetic irritation was inhibited when I preloaded an antibody of IL-6. IL-6 developed in rat dorsal root ganglia, spinal dorsal root and nerve injury region from the immediately after which nerve damage caused. I became a peak after nerve damage in three days and continued it to 14 after a disorder. This immunostaining result accords with course of rat pain-related behavioral degree. Rat sciatic nerve exposed was soaked into IL-6 solution, and it developed a pain-related behavior as CCI and CFA painful model. Intervention of IL-6 to neuropathic pain became clear. Early administration of an IL-6 blocker after nerve injury is effective as a therapy of neuropathic pain.
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