| Project/Area Number |
14571922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | TSURUMI UNIVERSITY |
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Principal Investigator |
SEKIYA Hideki SEKIYA,Hideki, 歯学部, 助手 (70267540)
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| Co-Investigator(Kenkyū-buntansha) |
SETO Kannichi TSURUMI UNIVERSITY, Dentistry, Professor, 歯学部, 教授 (60064367)
KONDOU Toshiroh Nihon University, Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70178416)
TAKAGAKI Yuko Kanagawa Dental Collage, Dentistry, Assistant Professor, 歯学部, 助教授 (60050689)
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| Project Period (FY) |
2002 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | OSTEOBLAST / OSTEOCYTE / MECHANICAL STRESS / BONE MARROW CELLS / PERIOSTUM CELLS / UDIFFERENTIATED CELLS / INTRACARTILAGE OSSFICATION / PERIOSTUS OSSIFICATION / 伸展刺激 / low-intensity pulsed ultrasound(LIPUS) / osteocyte / 仮骨延長術 / primary cell culture / osteoblast / human facial bone |
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| Research Abstract |
2002 : 1, Terms of latency period will control the differentiation of undifferentiated cells. 2, Stretched osteocytes mineralized themselves by taking Ca2+ into internal. 3, Early osteoblasts respond to the mechanical strain and differentiate mature one with upregulating COX m-RNA level.
2003 : 1, In the callous, differentiation of peri-periostum undifferentiated cells respond faster than that of cancellous bone cells. 2, In the peri-periostum area, the bridging of cartilage may transdifferentiate or make themselves apoptosis and then ossification. 3, The COX2-PGE2 synthesis in distraction osteogenesis may promote the ossification of cartilage. We must more investigate the mechanism of changing of cartilage by COX2.
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