Association between peruiodontal disease and pre-term/low birth weight.

• Project/Area Number: 14571986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Kagoshima University
• Principal Investigator: FURUICHI Yasushi Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (80305143)
• Co-Investigator(Kenkyū-buntansha): YOSHINAGA Mitsuhiro Kagoshima University Hospital, Associate Professor, 医学部・歯学部附属病院, 助教授 (00221672) ; MACHIGASHIRA Miho Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院・医歯学総合研究科, 助手 (80253897) ; MATSUYAMA Takashi Kagoshima University, Graduate School of Medical and Dental Sciences, Research Associate, 大学院・医歯学総合研究科, 助手 (40253900)
• Project Period (FY): 2002 – 2003
• Project Status: Completed (Fiscal Year 2003)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2002: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: periodontal disease / oral examination / pregnant women / threatened premature labor / pie-term birth / periodontpathic bacteria / cytokines / serum / 歯科検診 / 歯周病原性菌

Research Abstract

Threatened premature labor(TPL)often results in pie-term birth(PB).The aim of the present study was to evaluate the associations of periodontal and general health conditions with TPL and PB in relation to serum cytokine levels and the composition of subgingival plaque.
Eighty-eight women were enrolled in the study.Systemic, conditions were interviewed, and subgingival plaque samples obtained for bacterial analysis.Periodontal examinations included assessments of plaque, gingivitis, probing attachment level, probing pocket depth, and bleeding on probing.The serum cytokine levels were analyzed.Gestational age at delivery was recorded, and the mothers were divided into a TPL or non-TPL group, and into a non-TPL-TB(term birth), non-TPL-PB, TPL-TB or TPL-PB group, accordingly.
Forty subjects were TPL and 18 were TPL-PB.There were significant differences between the TPL and the non-TPL subjects in some of the systemic and periodontal parameters and serum cytokine levels.Significant differences were observed between the TPL-TB and TPL-PB in the percentage of Bacteroides forsythus(Bf), and the serum IL-8 and IL-lb levels.Significant negative correlations between the gestational age at delivery and some periodontal parameters and the serum IL-8 and IL-1b levels, and significant positive correlations between periodontal status and the serum IL-8 and IL-1b levels, were observed.The TPL women revealed worsened periodontal conditions and elevated serum IL-8 and IL-1b levels compared to the non-TPL women.
The elevated levels of serum IL-8 and IL-1b could have affected the maintenance of the proper uterinefetus relationship, resulting in premature uterine contractions.

Research Products

• [Publications] K.Hasegawa, Y.Furuichi, A.Shimotsu, M.Nakamura, M.Yoshinaga, M.Kamitomo, I.Maruyama, Y.Izumi: "Association between systematic status, periodontal status, serum cytokine levels and delivery outcomes in pregnant women with a diagnosis of threatened premature labor"Journal of Periodontology. 74,12. 1764-1770 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Hasegawa, K., Furuichi, Y., Shimotsu, A., Nakamura, M., Yoshinaga, M., Kamitomo, M., Hatae, M., Maruyama, I., Izumi, Y.: "Associations between systemic status, periodontal status, serum cytokine levels and delivery outcomes in pregnant women with a diagnosis of threatened premature labor(TPL)"Journal of Periodontology. 74. 1491-1497 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] K.Hasegawa, Y.Furuichi, A.Shimotsu, M.Nakamura, M.Yoshinaga, M.Kamitomo, I.Maruyama, Y.Izumi: "Association between systematic status, periodontal status, serum cytokine levels and delivery outcomes in pregnant women with a diagnosis of threatened premature labor"Journal of Periodontology. 74,12. 1764-1770 (2003)