| Project/Area Number |
14572019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
FURUKAWA Hiroshi Meijo University, Pharmacy, Professor, 薬学部, 教授 (00076712)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Chihiro Meijo University, Pharmacy, Associate Professor, 薬学部, 助教授 (60193497)
ITOIGAWA Masataka Human Wellnes Tokai-gakuenn University, Professor, 人間健康学部, 教授 (90168336)
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| Project Period (FY) |
2002 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Guttiferae / Leguminosae / Rutaceae / Euphorbiaceae / alkaloids / biological activity / coumarins / cinnamylphenols / イソフラボノイド / 発がんプロモーション抑制活性 / anti-HIV活性 / NO産制抑制活性 / Calophyllum属植物 / Dalbergia属植物 / cinnamylphenols / isoflavonoids / coumarins / Garcinia属植物 / xanthones / benzophenones / acridone alkaloids / 抗酸化活性 |
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| Research Abstract |
Plants contain many kinds of constituents and are a valuable source of new and biologically active molecules. The purpose of this project was the search of novel biologically active molecules from higher plants as a resource of possible anti-cancer agents. The summary of the results is shown below:
1. Isolation and Structure Elucidation of Plants Constituents: The scientific names of plants used and general names of isolated new compounds were shown below :
(1) Guttiferae Plants : Garcinia fusca (eight new xanthones), G. assigu (two new polyprenylated benzophenones), Calophyllum brasiliense (three new coumarins)
(2) Leguminosae Plants : Dalbergia cultrata, D. nigrescense, D. olibari (five new cinnamylphenols and two isoflavonoids), Milletia taiwaniana (five new isoflavonoids)
(3) Rutaceae Plants : Glycosm is arborea (three new carbazoles), Orixa japonica (four new quinolones), Murraya exotica (two new bicoumarins)
(4) Euphorbiaceae Plant : Croton jatrophoides (two new triterpenoids)
2. Biological activity assays for new and known plant constituents were carried out :
(1) Inhibitory effects on EBV-EA activation induced by TPA in Raji cells : benzophenones, cinnamylphenols, coumarins, acridones, carbazoles, phenyppropanoids, phytoquinoids.
(2) Inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis : acrid on es, isoflavonids.
(3) Radical scavenging ability against DPPH : benzophenones.
(4) Inhibitory effect of NO production in murine macrophage-like RAW 264.4 cells : quinolones, quinolines.
(5) Inhibition of leukemic cell growth : 4-substituted coumarins.
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