Development of New Chemopreventive Agents from Monascus pilosus-Fermented Rice (Red-Mold Rice)
| Project/Area Number |
14572101
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
医薬分子機能学
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
AKIHISA Toshihiro Nihon University, College of Science and Technology, Professor, 理工学部, 教授 (30060213)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOKUDA Harukuni Kyoto Prefectural University of Medicine, Department of Biochemistry, Assistant Professor, 生化学教室, 助手 (60111960)
YASUKAWA Ken Nihon University, College of Pharmacy, Professor, 薬学部, 教授 (00130625)
|
|---|
| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2002: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Monascus pilosus / red-mold rice / azaphilones / furanoisophthalides / amino acids / antitumor-promoter / antitumor-initiator / two-stage carcinogenesis / アザフィロイド類色素 / フラノソフタライド類色素 / がん予防物質 / EBV-EA発現抑制物質 / TPA誘発マウス耳殻炎症抑制物質 |
|---|
| Research Abstract |
Six azaphilones, monascin (1), ankaflavin (2), rubropunctatin (3), monascorburin (4), rubropunctamine (5), and monascorburamine (6), two furanoisophthalides, xanthomonasin A (7) and xanthomonasin B (8), and two amino acids, (+)-monascumic acid (9) and (-)-monascumic acid (10), isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice) were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate(TPA)-induced inflammation in mice, on the induction of Epstein-Barr virus early antigen(EBV-EA) by TPA in Raji cells, and on the activation of (±)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide(NO) donor. Among the compounds tested, seven compounds (1-6,and 10) on TPA-induced inflammation, and six compounds (1,3-5,9,and 10) on EBV-EA activation, exhibited potent inhibitory effects. All of the compounds tested showed moderate inhibitory effects on NOR 1 activation. Compound 1 was further evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO^-;PN) or by ultraviolet light B(UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate(TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN and UVB induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agents in chemical and environmental carcinogenesis.
|
Report
(4 results)
Research Products
(6 results)
-
-
[Journal Article] Azaphilones, Furanoisophthalides, and Amino Acids from the Extracts of Monascus pilosus-Fermented Rice (Red-Mold Rice) and Their Chemopreventive Effects2005
Author(s)
Toshihiro Akihisa, Harukuni Tokuda, Ken Yasukawa, Motohiko Ukiya, Ayaka Kiyota, Naoyuki Sakamoto, Takashi Suzuki, Nobukazu Tanabe, Hoyoku Nishino
-
Journal Title
Journal of Agricultural and Food Chemistry 53(3)
Pages: 562-565
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
