| Project/Area Number |
14572149
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
応用薬理学・医療系薬学
|
|---|
| Research Institution | FUKUSHIMA MEDICAL UNIVERSITY (2003-2004)
Tohoku University (2002) |
|---|
Principal Investigator |
TAKEBAYASHI Yuji Fukushima Medical University, School of Medicine Dept of Surgery II, Associate Professor, 医学部, 講師 (70321982)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKENOSHITA Seiichi Fukushima Medical University, School of Medicine Dept of Surgery II, Professor, 医学部, 教授 (10167489)
新田 康隆 東北大学, 歯学部, 助手 (80250794)
安井 明 東北大学, 加齢医学研究所, 教授 (60191110)
|
|---|
| Project Period (FY) |
2002 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | Cancer Chemotherapy / Metastasis / Membrane Transporter / DNA repair / Angiogenesis / 癌化学治療法 / 膜輸送体 |
|---|
| Research Abstract |
First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (CPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RTPCR and immunohistochemical analysis. The exprnssian levels of TP and TS were different between primary and metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in animal models.Unfortunately, the enhancement of these molecules were not obtained.
|
