| Project/Area Number |
15078203
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUSHIMA Kouji The University of Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (50222427)
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| Co-Investigator(Kenkyū-buntansha) |
高浜 洋介 徳島大学, ゲノム機能研究センター, 教授 (20183858)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥100,100,000 (Direct Cost: ¥100,100,000)
Fiscal Year 2006: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2005: ¥22,500,000 (Direct Cost: ¥22,500,000)
Fiscal Year 2004: ¥21,100,000 (Direct Cost: ¥21,100,000)
Fiscal Year 2003: ¥34,000,000 (Direct Cost: ¥34,000,000)
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| Keywords | chemokine / dendritic cells / virus / lymph node / migration / CTL / memory / ウイルス / TNF-α / 炎症 / 免疫組織 / 胸腺 / 免疫細胞移動 |
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| Research Abstract |
This project was intended to reveal the regulation of dynamic trafficking of subset of immune cells by chemokines to form immune-tissues in response to pathogen infection. As a result, the following points were found. 1. myeloid dendritic cells (mDCs) capture and process antigens, transport them from the tissue to the draining lymph nodes (LNs) and act as an antigen presenting cells, whereas plasmacytoid DCs (pDCs) directly migrate into inflamed LNs through HEV to help APC function of mDCs 2. nTreg home to the paracortex area of peripheral LNs through HEV in a CCR7 dependent manner and make cluster with subset of DCs 3. a primary response during re-challenge significantly contributes to memory T cell. Upon re-challenge, the skewed Vb usage and T-cell receptor (TCR) repertoire of pre-existing memory T cells is partly corrected by diversity in a newly primed (primary) T cell population. Importantly, this primary population expands more vigorously in a subsequent antigen encounter. These findings indicate that memory T cell populations evolve over multiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primary populations have essential roles in the perpetuation of antigen-specific T cell populations.
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