| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masaya Kyoto University, Institute for Frontier Medical Sciences, Assistant Professor (10332735)
UMEZAWA Akihiro Kyoto University, National Research Institute for Child Health and Development, Department of Reproductive Biology, Director (70213486)
YAMAOKA Tetsuji Kyoto University, National Cardiovascular Research Institute, Advance Medical Engineering Center, Director (50243126)
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| Budget Amount *help |
¥122,070,000 (Direct Cost: ¥93,900,000、Indirect Cost: ¥28,170,000)
Fiscal Year 2007: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2006: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2005: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2004: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2003: ¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
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| Research Abstract |
The objective of this research is to investigate and develop biomedical technologies and methodologies for the enhancement of stem cells proliferation and differentiation which is necessary to realize tissue regeneration therapy. Various 3-dimensional sponges and non-woven fabics of cell scaffold have been designed and prepared from different biodegradable polymers while the compatibility of scaffolds to cells is modified and improved by incorporating cell adhesion substances into them to and create functional scaffolds. In addition, bioreactor technologies are combined with the functional scaffold to promote the proliferation and differentiation of stem cells in vitro. The results obtained are as follows: The mechanical reinforcement of scaffolds by the incorporation of fibers, the surface modification of scaffolds with the self-assemble technology of alkanethiols, the improvement of scaffold cytocompatibility by the immobilization of cell adhesion substances, the promotion of cells proliferation and differentiation in vitro by combining the scaffold with various bioreactors. It is highly expected that all the results strongly contribute not only to the research acceleration of basic biology and medicine, but also the future development of tissue regeneration therapy.
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