| Project/Area Number |
15200049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Osaka University |
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Principal Investigator |
OHIRA Yoshinobu Graduate School of Medicine, Osaka University, Professor, 医学系研究科, 教授 (50185378)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANO Fuminori Graduate School of Medicine, Osaka University, Assistant, 医学系研究科, 助手 (90346156)
OHMI Shinobu Institute of Medical Science, University of Tokyo, Associate Professor, 医科学研究所, 助教授 (20160046)
OHIRA Yoshinobu Graduate School of Medicine, Osaka University, Professor (50185378)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
Fiscal Year 2006: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2005: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2004: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2003: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
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| Keywords | Skeletal muscle / Immune function / Proteomics / Regeneration / プロテオーム / 障害 / 老化 / 回復 / タンパク質 / 遺伝子 / 衛星細胞 |
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| Research Abstract |
It has been well-known that the decreases of morphological and/or functional properties of skeletal muscles, caused by growth retardation, injury, long-term bedrest, spaceflight, or aging, inhibit the quality of life in daily life. Therefore, it is essential to develop the suitable methodology for the promotion of recovery and/or regeneration of muscles with inhibited properties or injury. Role(s) of interleukin-6 (IL-6), macrophage, satellite cell, and mechanical and/or metabolic stimuli in the regulation of muscular properties in response to damage or regeneration were studied. As the results, it was suggested that satellite cells play one of the key roles in the plasticity of muscle. The number and activity of satellite cells were decreased in muscle with atrophy or damage. On the contrary, data indicated that the recoveries of these parameters are essential for the regeneration of muscle. It was also suggested that the number and activity of satellite cells are regulated by mechanical stimuli, heat stress, IL-6, and macrophage. Further, it was indicated that the responses of gene and protein expression in rat soleus muscle to growth retardation, caused by gravitational unloading, and recovery in 1-G environment did not always coincide.
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