| Project/Area Number |
15300116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NOGUCHI Koichi Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (10212127)
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| Co-Investigator(Kenkyū-buntansha) |
DAI Yi Hyogo College of Medicine, Faculty of Medicine, Assistant professor, 医学部, 講師 (20330441)
NISHIZAKI Tomoyuki Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (00221474)
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| Project Period (FY) |
2003 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥16,500,000 (Direct Cost: ¥16,500,000)
Fiscal Year 2006: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2005: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2003: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | DRG / nociception / pain / MAPK / ERK / p38 / primary afferent neurons / 細胞内シグナル / TRPA1 / 一次知覚ニューロン / ニューロパチックペイン / 侵害刺激 / 後根神経節 / P2X受容体 / パッチクランプ法 |
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| Research Abstract |
There is compelling evidence indicating that not only injured primary afferents, but also their spared neighbors, show an alteration of excitability and gene expression and that these changes have functional roles in nociception, inflammatory pan and neuropathic pain. We examined several forms of mitogen-activated protein kinases (MAPKs) dynamics in primary afferent neurons and also in spinal cord neurons following noxious stimuli to normal tissue or using inflammatory pain model or neuropathic pain model. In mammals, four major MAPK pathways have been discovered. They are the extracellular signal-regulated protein kinases 1/2 (ERK1/2), p38 MAPK, c-Jun N-terminal kinase (JNK), and ERK5. We examined a variety of phases of dynamics of MAPK in pain mechanisms and published 36 papers accepted in scientific journals.
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