Development of osteoconductive materials using ion conductive ceramics
| Project/Area Number |
15360338
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic materials/Physical properties
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKAMURA Satoshi Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (40227898)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Kimihiro Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor, 生体材料工学研究所, 教授 (70174670)
OHGAKI Masataka Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Assistant Professor, 生体材料工学研究所, 助手 (50223748)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2003: ¥8,700,000 (Direct Cost: ¥8,700,000)
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| Keywords | Hydroxyapatite / Ionic conductivity / Polarization / Oteoconductivity / Surface charges / Bioactive glass / Zirconia / Early stage cell adhesion / 電気分極 / 骨組織伝導 / セラミックス / 初期接着 / 吸着 / 細胞外基質 |
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| Research Abstract |
Large surface charges were demonstrated to be inducible on ionic conductive ceramics by ion transport polarization based on thermally stimulated depolarization measurements. We have been demonstrated by simulated body fluid tests that the negative, surface charges induced by the electrical polarization increased the overgrowth conductivity on the ionic conductive ceramic surface but that the positive charge diminished the overgrowth ability. The charge-induced surfaces of the ionic conductive ceramics promoted bone reconstructions in wide defects of canine bones at 7days after the implantation, whereas the processes varied according to the charge polarity. The idea of the activated field concerning the in vitro overgrowth should be extensible into the in vivo calcification reactions of the electrically polarized ionic conductive ceramics implanted in bone tissues. Moreover, we have proved that the electrical polarization techniques were applicable not only to hydroxyapatite but also to zirconia and bioactive glass and established the electrical polarization technologies for ionic conductive ceramics.
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Report
(4 results)
Research Products
(95 results)
