Influence to atherosclerosis development of adiponecine and insulin resistance : A community base study

• Project/Area Number: 15390206
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Sapporo Medical University School of Medicine
• Principal Investigator: SAITOH Shigeyuki Sapporo Medical University, Assistant professor, 医学部, 講師 (60253994)
• Co-Investigator(Kenkyū-buntansha): TAKAGI Satoru Sapporo Medical University, Assistant, 医学部, 助手 (20295348) ; HIGASIURA Katuhiro Sapporo Medical University, Assistant professor, 医学部, 講師 (10295347) ; URA Nobuyuki Sapporo Medical University, Associate professor, 医学部, 助教授 (20185078) ; SHIMAMOTO Kazuaki Sapporo Medical University, Professor, 医学部, 教授 (40136940)
• Project Period (FY): 2003 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥6,700,000 (Direct Cost: ¥6,700,000); Fiscal Year 2004: ¥2,000,000 (Direct Cost: ¥2,000,000); Fiscal Year 2003: ¥4,700,000 (Direct Cost: ¥4,700,000)
• Keywords: adiponectin / insulin resistance / communities based study / epidemiology / sex hormones / renal function / risk factors / Metabolic Syndrome

Research Abstract

Adiponectin, which is secreted specifically by adipose tissue, has been shown to have an anti-atherosclerotic effect and to improve insulin resistance. The aims of this study were to determine the correlations of plasma adiponectin concentration with insulin resistance, atherosclerosis and its risk factors and to determine the association between aging and adiponectin level from the aspect of influence of renal function and sex hormones in humans.
The subjects were 383 male inhabitants in two rural communities in Hokkaido, Japan. A negative correlation was found between homeostasis model assessment (HOMA) as an index of insulin resistance and adiponectin concentration. hCRP and pulse wave velocity (PWV) were used as an index of atherosclerosis. Results of stepwise regression analysis for adiponectin showed that age, HOMA and serum triglyceride (TG) were independently correlated. with adiponectin. A significant negative correlation was found between adiponectin and hCRP in all subjects, and a significant negative correlation between adiponectin and PWV was also found.
Serum adiponectin and blood urea nitrogen (BUN) levels were measured in 964 subjects aged 60ア 13 years. Testosterone and free testosterone levels were measured in 123 males, and estrone and estradiol levels were measured in 114 females. Adiponectin level increased linearly with aging in males, while it increased dramatically in females until their 50s. The patterns of changes in adiponectin were similar to those in BUN. In multiple regression analysis using adiponectin as a dependent variable, BUN was selected as a significant independent variable in subjects, while bioactive sex hormones were not selected as significant independent variables. A decrease in adiponectin clearance in the kidney may cause high levels of adiponectin in the elderly. Adiponectin level seems to be influenced more strongly by BUN than by sex hormones and to be increased by a decline in renal function with aging.

Research Products

• [Journal Article] Incidence of insulin restance in obese subjects in a rural Japanese population : The Tanno and Sobetsu study. (2005)
  • Author(s): Ohonishi H, Saitoh S, Takagi S, et al.
  • Journal Title: Diabetes, Obesity and Metabolism 7 Pages: 83-87
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 腹部超音波法と腹囲による男性内臓脂肪蓄積評価と動脈硬化危険因子の関連-瑞野・壮瞥町研究- (2005)
  • Author(s): 千葉雄, 斎藤重幸, 高木覚, 他
  • Journal Title: 日循予防誌 40 Pages: 9-14
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Metabolic syndrome and cardiac disease in Japanese Men : Applicability of the concept of metabolic syndeome defined by the NCEP-ATPIII (2005)
  • Author(s): Takeuchi H, Saitoh S, Takagi S, et al.
  • Journal Title: Hypertension Research 28(In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Influence of Gender, age and renal function on adiponectine level : The Tanno and Sobetsu study (2005)
  • Author(s): Isobe T, Saitoh S, Takagi S, et al.
  • Journal Title: European Journal of Endocrinology 152(In press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Incidence of insulin restance in obese subjects in a rural Japanese population : The Tanno and Sobetsu study (2005)
  • Author(s): Ohonishi H, Saitoh S, Takagi S, Ohata J, Takeuchi H, Isobe T, Katoh N, Chiba Y, Fujiwara T, Akasaka H, Shimamoto K.
  • Journal Title: Diabetes, Obesity and Metabolism 7 Pages: 83-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between visceral fat assessed by ultrasonography and waist circumference and accumulation of cardiovascular disease risk factors (2005)
  • Author(s): Chiba Y, Saitoh S, Takagi S, Isobe T, Takeuchi H, Katoh N, Fujiwara T, Akasaka H, Shimamoto K.
  • Journal Title: JJCDP 40 Pages: 9-14
  • NAID: 10029553611
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relation of hypertension and glucose tolerance impairment in elderly people to the development of arteriosclerosis : Investigation using pulse wave velocity (2005)
  • Author(s): Isobe T, Saitoh 8, Takagi S, Takeuchi H, Katoh N, Chiba Y, Fujiw ara T, Akasaka H, Shimamoto K.
  • Journal Title: Geriatric and Gerontology International 5 Pages: 10-16
  • NAID: 10013681834
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Influence of gender, age and renal function on plasma adiponectin level-the Tanno and Sobetsu study (2005)
  • Author(s): Isobe T, Saitoh S, Takagi S, Takeuchi H, Katoh N, Chiba Y, Fujiwara T, Akasaka H, Shimamoto K.
  • Journal Title: European J Endocrinology 125(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Metabolic syndrome and cardiac disease in Japanese men : applicability of the concept of metabolic syndrome defined by the NCEP-ATPIII to Japanese men-the Tanno and Sobetsu study (2005)
  • Author(s): Takeuchi H, Saitoh S, Takagi S, Ohonishi H, Ohata J, Isobe T, Shimamoto K.
  • Journal Title: Hypertens. Res. 28(in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 腹部超音波法と腹囲による男性内蔵脂肪蓄積評価と動脈硬化危険因子の関連-端野・壮瞥町研究- (2005)
  • Author(s): 千葉雄, 斎藤重幸, 高木覚, 他
  • Journal Title: 日循予防誌 40 Pages: 9-14
• [Journal Article] Influence of Gender, age and renal function on adiponectine level The Tanno and Sobetsu study (2005)
  • Author(s): Isobe T, Saitoh S, Takagi S, et al.
  • Journal Title: European Journal of Endocrinology 152(in press)
• [Journal Article] Prevalence of asymptomatic arteriosclerosis obliterance and its relationship with risk factors in inhabitants of rural communities in Japan (2004)
  • Author(s): Fujiwara T, Saitoh S, Takagi S, et al.
  • Journal Title: Atherosclerosis 177 Pages: 83-88
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Correlation of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations. (2004)
  • Author(s): Higashiura K, Saitoh S, Shimamoto K, et al.
  • Journal Title: Clinical Endocrinology 61 Pages: 753-759
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Adiponectin levels and coronary risk factors in the elderly (2004)
  • Author(s): Isobe T, Saitoh S, Takagi S, Ohonishi H, Ohata J, Takeuchi H, Katoh N, Chiba Y, Fujiwara T, Akasaka H, Shimamoto K.
  • Journal Title: Jpn. J Geriat. 41 Pages: 328-333
  • NAID: 10014384916
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prevalence of asymptomatic arteriosclerosis obliterance and its relationship with risk factors in inhabitants of rural communities in Japan : Tanno-Sobetsu study (2004)
  • Author(s): Fujiwara T, Saitoh S, Takagi S, Ohnishi H, Ohata J, Isobe T, Takeuchi H, Chiba Y, Katoh N, Akasaka H, Shimamoto K.
  • Journal Title: Atherosclerosis 177 Pages: 83-88
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Correlation of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations (2004)
  • Author(s): Higashiura K, Ura N, Ohata J, Togashi N, Takagi S, Saitoh S, Murakami H, Takagawa Y, Shimamoto K.
  • Journal Title: Clinical Endocrinology 61 Pages: 753-759
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 耐糖能異常合併と血圧レベル別の心血管疾患死亡 (2004)
  • Author(s): 中村陽介, 斎藤重幸, 高木覚, 他
  • Journal Title: 医学のあゆみ 210 Pages: 717-718
• [Publications] 磯部 健, 斎藤重幸 他: "高齢者におけるアディポネクチンと冠動脈危険因子の関連-端野・壮瞥研究-"日本老年医学会雑誌. 41(3)(掲載予定). (2004)
• [Publications] 大西浩文, 斎藤重幸, 島本和明: "耐糖能異常における動脈硬化の指標としての脈波伝播速度-端野・壮瞥研究-"Arterial Stiffness. 5. 15-18 (2004)