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Serotonin transporter loss and psychotic state in methamphetamine users

Research Project

Project/Area Number 15390349
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

MINABE Yoshio  Hamamatsu University School of Medicine, School of Medicine, Associate Professor, 医学部附属病院, 講師 (60181947)

Co-Investigator(Kenkyū-buntansha) MORI Norio  Hamamatsu University School of Medicine, School of Medicine, Professor, 医学部, 教授 (00174376)
TAKEI Noriyoshi  Hamamatsu University School of Medicine, School of Medicine, Associate Professor, 医学部, 助教授 (80206937)
NAKAMURA Kazuhiko  Hamamatsu University School of Medicine, School of Medicine, Associate Professor, 医学部附属病院, 講師 (80263911)
TOYOTA Takao  Hamamatsu University School of Medicine, School of Medicine, Assistant Professor, 医学部附属病院, 助手 (70334977)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 2004: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥4,500,000 (Direct Cost: ¥4,500,000)
Keywordsmethamphetamine / serotonin transpoter / aggression / PET / proton MRS / toluene / human
Research Abstract

Background : In animals, methamphetamine is known to have a neurotaxic effect on seroronin neurons, which have been implicated in the regulation of mood, anxiety, and aggression. However, it remains unknown whether or not methamphetamine damages serotonin neurons in humans.
Objective : To investigate the status of brain serotonin neurons and their possible relationship with clinical characteristics in currently abstinent former methamphetamine abusers.
Desigh : The brain regional density of the serotonin transporter, a structural component of serotonin neurons, was estimated in the brain using positron emission tomography (PET) and [^<11>C](+)McN-5652. A case-control analysis was performed with the estimates derived from region-of-interest (ROI) and statistical parametric mapping (SPM) methods, followed by within-case analysis with the measures of clinical variables.
Setting : Partieipants were recruited from the community to a hospital research center.
Participants : Twelve currently abst … More inent former methamphetamine abusers (5 women, 7 men) and age-, gender-, and twelve education-matched healthy control subjects (5 women, 7 men).
Main Outcome Measures : The duration of methamphetamine use, magnitude of aggression and depressive symptoms, and changes in serotonin transporter density represented by the [^<11>C](+)McN-5652 distribution volume.
Results : The methamphetamine abusers showed increased levels of aggression compared to those of the control subjects. Both ROI and SPM analyses revealed that the serotonin transporter density in global brain regions (eg, midbrain, thalamus, caudate, putamen, cerebral cortex, and cerebellum) was significantly lower in the methamphetamine abusers than in the control subjects, and this reduction was found to be significantly inversely correlated with the duration of methamphetamine use. Furthermore, SPM analyses indicated that the density in the orbitofrontal, temporal, and anterior cingulate areas was closely associated with the magnitude of aggression in methamphetamine abusers.
Conclusions : Protracted abuse of methamphetamine may reduce the density of the serotonin transporter in the brain, leading to elevated aggression, even among those in a currently abstinent state. Less

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (5 results)

All 2005 2004 Other

All Journal Article (4 results) Publications (1 results)

  • [Journal Article] Reduced brain serotonin transporters associated with elevated aggression in abstinent methamphetamine abusers2005

    • Author(s)
      K, Sekine Y, Ouchi Y, Takei N, Minabe Y et al.
    • Journal Title

      Archives of General Psychiatry (In Press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reduced brain serotonin transporters associated with elevated aggression in abstinent methamphetamine abusers2005

    • Author(s)
      K, Sekine Y, Ouchi Y, Takei N, Minabe Y et al.
    • Journal Title

      Archives of General Psychiatry (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Reduced brain serotonin transporters associated with elevated azaression in abstinent methamnhetamine abusers2005

    • Author(s)
      K, Sekine Y, Ouchi Y, Takei N, Minabe Y et al.
    • Journal Title

      Archives of General Psychiatry in press

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Metabolite alterations in basal ganglia associated with psychiatric symptoms of abstinent toluene users : A proton MRS study2004

    • Author(s)
      Takebayashi K, Sekine Y, Takei N, Minabe Y et al.
    • Journal Title

      Neuropsychopharmacology 29

      Pages: 1019-1026

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Publications] 三辺 義雄: "覚醒剤使用者のセロトニン・トランスポーター脳内密度と精神症状との関連に関する研究"平成15年度精神薬療研究年報. (印刷中).

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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