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Activation and regulation of oncogenic signaling networks in colorectal cancer

Research Project

Project/Area Number 15390391
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKanazawa University

Principal Investigator

MINAMOTO Toshinari  Kanazawa University, Cancer Research Institute, Professor, がん研究所, 教授 (50239323)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Yutaka  Kanazawa University, Cancer Research Institute, Associate Professor, がん研究所, 助教授 (10179541)
磨伊 正義  金沢大学, がん研究所, 教授 (80092807)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2004: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsColorectal cancer / Oncogenic signaling / β-catenin / Ubiquitin system / β-TrCP / NF-κB / RNA trans-acting factor / GSK3β / がん分子標的 / ELISA / 血清分子診断 / 大腸がん / ユビキチン化分解 / β-TrCP E3ユビキチンリガーゼ / 分子標的 / RASがん化シグナル
Research Abstract

A promising area in current cancer research explores the wide range of molecular events including aberrant/alternative gene splicing, epigenetic changes, cellular signal transduction, transcriptional regulation and post-translational modifications, which determine the fate of cells (growth, differentiation, and programmed cell death). One of such events takes place in the Wnt signaling pathway, and its aberrant activation is involved in malignant transformation of cells, β-catenin has two distinct functions, namely, maintaining cell-to-cell adhesion and mediating the Wnt/β-catenin pathway, which plays pivotal roles in embryogenesis and in certain tumors, particularly development and progression of colorectal cancer (CRC)^<16>. On the basis of our previous studies showing association of distinct patterns of β-catenin activation with malignant potential of the tumors and clinical outcome of CRC patients^6, in the present study we addressed the molecular and cellular mechanisms underlying … More activation and deregulation of Wnt/β-catenin signaling in colorectal cancer.
The oncogenic properties of Wnt/β-catenin signaling stem from alteration in ubiquitin-mediated degradation and subcellular localization of β-catenin from cell membrane to the nucleus, where it binds to T cell factor (Tcf) ; the complex facilitates transcription of genes encoding factors for cell proliferation and inhibition of apoptosis. We previously found that β-transducin repeat-containing protein (β-TrCP) is a component of the ubiquitin ligase complex targeting β-catenin and IκBα for proteasomal degradation and thus a negative regulator of Wnt/β-catenin signaling and a positive regulator of NF-κB pathway. Increased induction of β-TrCP via the β-catenin/Tcf pathway results in degradation of β-catenin, indicating that a negative feedback loop controls the β-catenin/Tcf pathway under physiologic conditions (Mol Cell 2000;5:877-82). Here we demonstrated that, in CRC, increased expression of β-TrCP by an impairment in the negative feedback loop regulation between β-TrCP and β-catenin is associated with activation of both β-catenin and NF-κB, suggesting that the integration of these signaling pathways by β-TrCP overexpresion contributes to an inhibition of apoptosis and tumor metastasis^9.
As mentioned above, in non-neoplastic cells harboring wild-type CTNNB1 and APC genes, β-catenin/Tcf signaling increases levels of β-TrCP mRNA and protein in a Tcf-dependent manner (Mol Cell 2000;5:877-82). In this study, we identified a novel β-catenin/Tcf target gene X ; protein product of which binds to the coding region of β-TrCP1 mRNA and stabilizes it. It was also demonstrated that X protein is essential for induction of mRNA of β-TrCP1 as well as c-myc by β-catenin/Tcf signaling in colon cancer cells. In human CRC, increased expression of X protein and β-TrCP coincides with activation of β-catenin and NF-κB in the same tumor, which is associated, with inhibition of apoptosis and tumor metastasis (unpublished data).
With regards to the canonical view that GSK3β is a negative regulator of Wnt signaling, one may consider that it functions like a tumor suppressor in CRC. Reportedly GSK3β has opposing roles ; removing a neoplastic trigger by phosphorylation-dependent degradation of β-catenin in the ubiquitin system, and maintaining cell survival and proliferation through the NF-κB pathway. Here we demonstrated an unrecognized role (tumor supportive properties) of GSK3β in CRC by transcriptionally and pharmacologically modulating its expression and activity, and warrant proposing this kinase as a potential therapeutic target in CRC^<14>. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (55 results)

All 2006 2005 2004 2003 Other

All Journal Article (43 results) Book (3 results) Patent(Industrial Property Rights) (2 results) Publications (7 results)

  • [Journal Article] c-kit gene mutation is common and widely distributed in intracranial germinomas2006

    • Author(s)
      Kamakura Y, Minamoto T, et al.
    • Journal Title

      Journal of Neurosurgery (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection2006

    • Author(s)
      Maenaka S, Minamoto T, et al.
    • Journal Title

      Oncology Report (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] c-kit gene mutation is common and widely distributed in intracranial germinomas.2006

    • Author(s)
      Kamakura Y, Hasegawa M, Kida S, Tachibana O, Okamoto Y, Minamoto T, Yamashita J, Fujisawa H.
    • Journal Title

      J Neurosurg (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection.2006

    • Author(s)
      Maenaka S, Hikichi T, Imai-Akasofu M, Minamoto T, Kawahara E.
    • Journal Title

      Oncol Rep (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A full genome scan for gastric cancer2005

    • Author(s)
      Aoki M, Minamoto T, et al.
    • Journal Title

      Journal of Medical Genetics 42・1

      Pages: 83-87

    • NAID

      120001130409

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Correlation of γ-catenin expression with good prognosis in medulloblastomas2005

    • Author(s)
      Misaki K, Minamoto T, et al.
    • Journal Title

      Journal of Neurosurgery (Pediatrics 2) 102・2

      Pages: 197-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Adhesiveness of β5 integrin variant lacking FNK^<767-769> is similar to that of the prototype containing FNKFNK^<767-769>2005

    • Author(s)
      Kawahara E, Minamoto T, et al.
    • Journal Title

      Cell Biology International 29・7

      Pages: 521-528

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Deregulated GSK3β activity in colorectal cancer : its association with tumor cell survival and proliferation2005

    • Author(s)
      Shakoori A, ct al., Takahashi Y, Minamoto T.
    • Journal Title

      Biochemical and Biophysical Research Communications 334・4

      Pages: 1365-1373

    • NAID

      120000812884

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population2005

    • Author(s)
      Aoki M, Minamoto T, et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 335・2

      Pages: 566-574

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Oneogenic β-catenin signaling networks in colorectal cancer2005

    • Author(s)
      Fuchs SY, et al., Minamoto T.
    • Journal Title

      Cell Cycle 4・11

      Pages: 1522-1539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions : K-ras oncogene in non-ncoplastic tissue and aberrant crypt foci of colorectal cancer patients.2005

    • Author(s)
      Minamoto T.
    • Journal Title

      Molecular Toxicology Protocols/Methods of Molecular Biology (Keohavong P and Grant S, eds.)(Humana Press, Totawa, NJ) Vol.291

      Pages: 263-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M, Yamamura Y, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Takahashi T, Akagi K, Sairenji M, Yamamoto K, Sasazuki T.
    • Journal Title

      J Med Genet 42(1)

      Pages: 83-87

    • NAID

      120001130409

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Correlation of γ-catenin expression with good prognosis in medulloblastomas.2005

    • Author(s)
      Misaki K, Marukawa K, Hayashi Y, Fukusato T, Minamoto T, Hasegawa M, Yamashita J, Fujisawa H.
    • Journal Title

      J Neurosurg (Pediatrics 2) 102

      Pages: 197-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Adhesiveness of β5 integrin variant lacking FNK^<767-769> is similar to that of the prototype containing_FNKFNK^<767-769>.2005

    • Author(s)
      Kawahara E, Saito A, Kobayashi J, Maenaka S, Minamoto T, Akasofu-Imai M, Oda Y.
    • Journal Title

      Cell Biol Int 29(7)

      Pages: 521-528

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Deregulated GSK3β activity in colorectal cancer : its association with tumor cell survival and proliferation.2005

    • Author(s)
      Shakoori A, Ougolkov A, Yu ZW, Zhang B, Modarressi MH, Billadeau DD, Mai M, Takahashi Y, Minamoto T.
    • Journal Title

      Biochem Biophys Res Commun 334(4)

      Pages: 1365-1373

    • NAID

      120000812884

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.2005

    • Author(s)
      Aoki M, Yamamoto K, Ohyama S, Yamamura Y, Takenoshita S, Sugano K, Minamoto T, Kitajima M, Sugimura H, Shimada S, Noshiro H, Hiratsuka M, Sairenji M, Ninomiya I, Yano M, Uesaka K, Matsuno S, Maehara Y, Aikou T, Sasazuki T.
    • Journal Title

      Biochem Biophys Res Commun 335(2)

      Pages: 566-574

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Oncogenic β-catenin signaling networks in colorectal cancer.2005

    • Author(s)
      Fuchs SY, Ougolkov AV, Spiegelman VS, Minamoto T.
    • Journal Title

      Cell Cycle 4(11)

      Pages: 1520-1537

    • NAID

      120000812645

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Deregulated GSK3β activity in colorectal cancer : its association with tumor cell survival and proliferation2005

    • Author(s)
      Shakoori A, et al., Takahashi Y, Minamoto T
    • Journal Title

      Biochemical and Biophysical Research Communications 334・4

      Pages: 1365-1373

    • NAID

      120000812884

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oncogenic β-catenin signaling networks in colorectal cancer2005

    • Author(s)
      Fuchs SY, et al., Minamoto T
    • Journal Title

      Cell Cycle 4・11

      Pages: 1522-1539

    • NAID

      120000812645

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A full genome scan for gastric cancer.2005

    • Author(s)
      Aoki M, Minamoto T, et al.
    • Journal Title

      Journal of Medical Genetics 42・1

      Pages: 83-87

    • NAID

      120001130409

    • Related Report
      2004 Annual Research Report
  • [Journal Article] γ-catenin expression correlates with good prognosis in medulloblastomas.2005

    • Author(s)
      Misaki K, Minamoto T, et al.
    • Journal Title

      Journal of Neurosurgery : Pediatrics (印刷中)

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Oncogenic β-catenin signaling network in colorectal cancer.2005

    • Author(s)
      Fuchs SY, et al.Minamoto T
    • Journal Title

      Cell Cycle (印刷中)

    • NAID

      120000812645

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Pilot study of low dose, divided maximum tolerated dose of CPT-11 in 21 consecutive patients with metastatic colorectal or gastric cancer2004

    • Author(s)
      Takahashi Y, Minamoto T, et al.
    • Journal Title

      Surgery Today 34・3

      Pages: 246-250

    • NAID

      10014172519

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epidermoid cyst of the intrapancreatic accessory spleen producing CA19-92004

    • Author(s)
      Watanabe H, Minamoto T, et al.
    • Journal Title

      Digestive Endoscopy 16・3

      Pages: 244-248

    • NAID

      10016171404

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin and NF-κB in colorectal cancer2004

    • Author(s)
      Ougolkov A, et al., Minamoto T.
    • Journal Title

      Journal of National Cancer Institute 96・15

      Pages: 1161-1170

    • NAID

      120000812221

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pilot study of low dose, divided maximum tolerated dose of CPT-11 in 21 consecutive patients with metastatic colorectal or gastric cancer.2004

    • Author(s)
      Takahashi Y, Kitakata H, Yamashita K, Yasumoto K, Omote K, Minamoto T, Mai M.
    • Journal Title

      Surg Today 34(3)

      Pages: 246-250

    • NAID

      10014172519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Epidermoid cyst of the intrapancreatic accessory spleen producing CA19-9.2004

    • Author(s)
      Watanabe H, Yamaguchi Y, Ohtsubo K, Mouri H, Motoo Y, Yamashita K, Minamoto T, Gabata T, Sawabu N.
    • Journal Title

      Digest Endosc 16(3)

      Pages: 244-248

    • NAID

      10016171404

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin and NF-κB in colorectal cancer.2004

    • Author(s)
      Ougolkov A, Zhang B, Yamashita K, Bilim V, Mai M, Fuchs SY, Minamoto T.
    • Journal Title

      J Natl Cancer Inst 96(15)

      Pages: 1161-1170

    • NAID

      120000812221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Pilot study of low dose, divided maximum tolerated dose of CPT-11 in 21 consecutive patients with metastatic coloretal or gastric cancer.2004

    • Author(s)
      Takahashi Y, Minamoto T, et al.
    • Journal Title

      Surgery Today 34・4

      Pages: 246-250

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Epidermoid cyst of the intrapancreatic accessory spleen producing CA19-9.2004

    • Author(s)
      Watanabe H, Minamoto T, et al.
    • Journal Title

      Digestive Endoscopy 16・3

      Pages: 244-248

    • NAID

      10016171404

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Associations among β-TrCP, an E3 ubiquitin ligase receptor, β-catenin and NF-κB in colorectal cancer.2004

    • Author(s)
      Ougolkov A, Takahashi Y, et al.
    • Journal Title

      Journal of the National Cancer Institute 96・15

      Pages: 1161-1170

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Abnormal expression of E-eadherin, β-catenin and c-erbB-2 in gastric cancer with liver metastasis2003

    • Author(s)
      Ougolkov A, Takahashi Y, et al., Minamoto T.
    • Journal Title

      International Journal of Colorectal Disease (Clinical and Molecular Gastroenterology and Surgery) 18・2

      Pages: 160-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Visualizing the gastric wall with a 30-MHz ultrasonic miniprobe : cx vivo imaging of normal gastric sites and sites of early gastric cancer2003

    • Author(s)
      Sabet EA, Minamoto T, et al.
    • Journal Title

      Abdominal Imaging 28・2

      Pages: 252-256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Virchow's Archive2003

    • Author(s)
      Morita H, Minamoto T, et al.
    • Journal Title

      Collagenofibrotic glomerulopathy with a widespread expression of type V collagen 442・2

      Pages: 163-168

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Endosonographie evaluation of c-kit-positive gastrointestinal stromal tumor2003

    • Author(s)
      Okai T, Minamoto T, et al.
    • Journal Title

      Abdominal Imaging 28・3

      Pages: 301-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of αv integrin family in gastric carcinomas : increased αvβ6 is associated with lymph node metastasis2003

    • Author(s)
      Kawashima A, Minamoto T, et al.
    • Journal Title

      Pathology Research and Practice 199・2

      Pages: 57-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] β-catenin and ras oncogenes detect most human colorectal cancers2003

    • Author(s)
      Zhang B, Takahashi Y, et al., Minamoto T.
    • Journal Title

      Clinical Cancer Research 9・8

      Pages: 3073-3079

    • NAID

      120000812387

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Abnormal expression of E-cadherin, β-catenin and c-erbB-2 in gastric cancer with liver metastasis.2003

    • Author(s)
      Ougolkov A, Yamashita K, Bilim V, Takahashi Y, Mai M, Minamoto T.
    • Journal Title

      Int J Colorect Dis (Clin Mol Gastrocnterol Surg) 18(2)

      Pages: 160-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Visualizing the gastric wall with a 30-MHz ultrasonic miniprobe : ex vivo imaging of normal gastric sites and sites of early gastric cancer.2003

    • Author(s)
      Sabet EA, Okai T, Minamoto T, Mai M, Sawabu N
    • Journal Title

      Abdom Imaging 28(2)

      Pages: 252-256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Collagenofibrotic glomerulopathy with a widespread expression of type V collagen.2003

    • Author(s)
      Morita H, Hasegawa T, Minamoto T, Oda Y, Inui K, Tayama H, Nakao N, Ideura T, Yoshimura A.
    • Journal Title

      Virchow's Archiv 442(2)

      Pages: 163-168

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Endosonographic evaluation of c-kit-positive gastrointestinal stromal tumor.2003

    • Author(s)
      Okai T, Minamoto T, Ohtsubo K, Minato H, Kurumaya H, Oda Y, Mai M, Sawabu N.
    • Journal Title

      Abdom Imaging 28(3)

      Pages: 301-307

    • NAID

      120000811915

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Expression of αv integrin family in gastric carcinomas : increased αvβ6 is associated with lymph node metastasis.2003

    • Author(s)
      Kawashima A, Tsugawa S, Boku A, Kobayashi M, Minamoto T. Nakanishi I, Oda Y.
    • Journal Title

      Pathol Res Prac 199(2)

      Pages: 57-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] β-catenin and ras oncogenes detect most human colorectal cancers.2003

    • Author(s)
      Zhang B, Ougolkov A, Yamashita K, Takahashi Y, Mai M, Minamoto T.
    • Journal Title

      Clin Cancer Res 9(8)

      Pages: 3073-3079

    • NAID

      120000812387

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Book] Molecular Toxicology Protocols/Methods of Molecular Biology(Keohavong P and Grant S, eds.)2005

    • Author(s)
      Minamoto T
    • Total Pages
      489
    • Publisher
      Humana Press
    • Related Report
      2005 Annual Research Report
  • [Book] Methods in Molecular Biology/Molecular Toxixology Protocols(Keohavong P, Grant S, eds.)2005

    • Author(s)
      Minamoto T
    • Total Pages
      489
    • Publisher
      Humana Press
    • Related Report
      2004 Annual Research Report
  • [Book] Molecular Toxicology Protocols/Methods of Molecular Biology Vol 2912004

    • Author(s)
      Minamoto T.
    • Total Pages
      489
    • Publisher
      Humana Press(Keohavong P, Grant S, eds.)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] GSK3β阻害効果に基づくがんの抑制および抗がん剤の評価方法2006

    • Inventor(s)
      源 利成
    • Industrial Property Rights Holder
      国立大学法人金沢大学
    • Filing Date
      2006-01-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] GSK3β阻害効果に基づくがんの抑制および抗がん剤の評価方法2006

    • Inventor(s)
      源 利成
    • Industrial Property Rights Holder
      国立大学法人金沢大学
    • Filing Date
      2006-01-04
    • Related Report
      2005 Annual Research Report
  • [Publications] Ougolkov A, Minamoto T, et al.: "Abnormal expression of E-cadherin, β-catenin and c-erbB-2 in gastric cancer with liver metastasis"Int J Colorect Dis (Clin Mol Gastroenterol Surg). 18・2. 160-166 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sabet EA, Minamoto T, et al.: "Visualizing the gastric wall with a 30-MHz ultrasonic miniprobe : ex vivo imaging of normal gastric sites and sites of early gastric cancer"Abdom Imaging. 28・2. 252-256 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Morita H, Minamoto T, et al.: "Collagenofibrotic glomerulopathy with a widespread expression of type V collagen"Virchow's Archiv. 442・2. 163-168 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okai T, Minamoto T, et al.: "Endosonographic evaluation of c-kit-positive gastrointestinal stromal tumor"Abdom Imaging. 28・3. 301-307 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawashima A, Minamoto T, et al.: "Expression of αv integrin family in gastric carcinomas : increased αvβ6 is associated with lymph node metastasis"Pathol Res Prac. 199・2. 57-64 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Zhang B, Minamoto T, et al.: "β-catenin and ras oncogenes detect most human colorectal cancers"Clin Cancer Res. 9・8. 3073-3079 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minamoto T.: "Molecular Toxicology Protocols/Methods of Molecular Biology"Keohavong P and Grant S, eds., Humana Press(印刷中). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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