| Project/Area Number |
15390435
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
TAKI Waro Mie University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (70144368)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IWATA Hiroo Kyoto University, Institute for Frontier Medical Sciences, Professor, 再生医科学研究所, 教授 (30160120)
MATSUSHIMA Satoshi Mie University, Graduate School of Medicine, Associate professor, 大学院・医学系研究科, 助教授 (50252367)
SAKAIDA Hiroshi Mie University Hospital, Lecturer, 医学部附属病院, 講師 (40273362)
KAWAGUCHI Kenji Mie University, Graduate School of Medicine, Assistant Professor, 大学院・医学系研究科, 助手 (90303742)
TOMA Naoki Mie University Hospital, Assistant Professor, 医学部附属病院, 助手 (80362341)
朝倉 文夫 三重大学, 医学部, 助手 (90322362)
|
|---|
| Project Period (FY) |
2003 – 2005
|
| Project Status |
Completed (Fiscal Year 2005)
|
| Budget Amount *help |
¥13,900,000 (Direct Cost: ¥13,900,000)
Fiscal Year 2005: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2004: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2003: ¥4,800,000 (Direct Cost: ¥4,800,000)
|
|---|
| Keywords | intracranial aneurysm / endovascular therapy / medical technology / medical device / bioactive agent / coil / stent |
|---|
| Research Abstract |
Endovascular treatment of intracranial aneurysms with detachable platinum coils, has been widely accepted as a less invasive alternative to standard surgical clipping. An endovascular approach, however, produces a higher incidence of recurrence compared with surgical clipping, especially in large and giant aneurysms. Histological analysis of aneurysms in human autopsy cases has demonstrated a lack of clot organization in the lumens, probably due to the relative biological inertness of platinum coils. Therefore, to enhance the repair processes, a variety of surface modifications of platinum coils for endovascular aneurysm treatment have been attempted in experimental studies. In this study, we developed vascular endothelial growth factor-immobilized platinum microcoils, basic fibroblast growth factor-immobilized platinum microcoils and tenascin-C-coated platinum coils. These new coils accelerated organization of cavities in a rat aneurysm model. We also developed ProNectin F-grafted-ethylene vinyl alcohol copolymer (EVAL) as a liquid type material for treating cerebral aneurysm, and gold stents for the treatment of intracranial aneurysms. These results suggest that these new endovascular devices may provide improved efficacy of endovascular embolization of intracranial aneurysm.
|
