Study of Alterations in Neurotrophin Expression in Chronic Spinal Cord Compression
| Project/Area Number |
15390443
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Dokkyo University School of Medicine |
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Principal Investigator |
KIM Phyo Dokkyo Univ., School of Medicine Dept.of Nerrosurbery, Professor, 医学部, 教授 (90231290)
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| Co-Investigator(Kenkyū-buntansha) |
OGINO Masahiro Dokkyo Univ., School of Medicine Dept.of Nerrosurbery, Assistant Professor, 医学部, 講師 (80224137)
KAWAMOTO Toshiki Dokkyo Univ., School of Medicine Dept.of Nerrosurbery, Assistant Professor, 医学部, 講師 (50301461)
ASAKUNO Keizou Dokkyo Univ., School of Medicine Dept.of Nerrosurbery, Assistant Professor, 医学部, 講師 (00316548)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 2004: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2003: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | Myelopathy / Chronic Spinal Cord Compression / Neurotrophic Factors / BDNF / NGF / 頚椎症性席髄症 / 遅発性運動障害 / 脊髄前角ニューロン / 神経細胞死 |
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| Research Abstract |
The regulation of neurotrophic factor expression in mild spinal cord compression has not been investigated in detail, especially in regards to their effects on motoneurons. Therefore, we investigated the levels of BDNF and NGF, in motoneurons of a rat spinal cord compression(SCC) model developed by us and control animals. The expression pattern of BDNF and NGF were examined in spinal segments C4,C5-6,C7 in SCC and control rats. BDNF expression in motoneurons increased at the compressed region in 25-week SCC rats. In contrast, βNGF expression in the motoneurons decreased gradually in all three segments. This decrease may be due to a decrease in the processing of proNGF, which promotes proNGF expression and decreases the levels of mature NGF. In 9-week SCC rats, intensely BDNF positive glial cells were observed in the anterior horn and white matter around the compressed region. These results suggest that the upregulation of BDNF contributes to regeneration in motoneurons and an improvement of motor paresis. In contrast, NGF may induce motoneuron apoptosis through increased proNGF levels, similar to changes observed in Alzheimer's disease.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Delayed Myelopathy Induced by Chronic Compression in the Rat Spinal Cord2004
Author(s)
Phyo Kim, MD, PhD, DMSc, Toshilhiko Haisa, MD, DMSc, Toshiki Kawamoto, MD, PhD, Takaaki Kirino, MD, DMSc, Susumu Wakai, MD, DMSC
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Journal Title
Ann Neurol 55
Pages: 503-511
Description
「研究成果報告書概要(欧文)」より
Related Report
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