| Project/Area Number |
15406013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | Osaka University |
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Principal Investigator |
AOZASA Katsuyuki Osaka University, Grad Sch Med, Prof., 医学系研究科, 教授 (30115985)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAKUWA Tetsuya Osaka University, Grad Sch Med, Assoc Prof, 医学系研究科, 助教授 (40244933)
HOSHIDA Yoshihiko Osaka University, Hosp, Assoc Prof, 医学部附属病院, 助教授 (40324777)
HONGYO Tadashi Osaka University, Grad Sch Med, Assoc Prof, 医学系研究科, 助教授 (90271569)
INOHARA Hidenori Osaka University, Grad Sch Med, Assistant Professor, 医学系研究科, 講師 (00273657)
西宇 美恵子 大阪大学, 医学系研究科, 助手 (90335349)
中塚 伸一 大阪大学, 医学系研究科, 助手 (90303940)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥10,200,000 (Direct Cost: ¥10,200,000)
Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2003: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | malignant lymphoma / NK / T cell / EB virus / pesticide / epidemiology / gene mutation / 鼻腔リンパ腫 / 農薬 / Epstein-Barrウィルス / p53 / 症例・対照研究 |
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| Research Abstract |
1. PCR-SSCP method followed with direct sequencing revealed the different frequency and pattern of p53, c-kit, k-ras, and β-catenin gene mutations in cases with nasal NK/T-cell lymphoma (NKTCL) between Japan, Korea, and northeast district of China. These findings suggest that life-style and genetical factors might be causative factors for NKTCL.
2. Subsequent epidemiological study on the life-style including pesticide use and NKTCL development revealed the important variables as follows : 4.15(CI:1.74-9.87) for farmers, 2.81(CI:1.49-5.29) for producers of crops, 5.21(CI:1.30-20.86) for pesticide users, 11.65(CI:1.17-115.82) for residents near garbage burning plants. Relative risk was lower in crop producers who minimized their exposure to pesticides by using gloves and glasses and sprinkling downward at the time of pesticide use, 0.11(CI:0.02-0.70), 0.18(CI;0.01-2.26), and 0.11(CI:0.02-0.66), respectively, than those who did not. These findings suggest the exposure to pesticides and chemical solvents could be causative of NKTCL.
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