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Neural mechanisms involved in the generation and regulation of hindlimb hopping movements in decerebrate rabbits.

Research Project

Project/Area Number 15500287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionSapporo Medical University

Principal Investigator

MATSUYAMA Kiyoji  Sapporo Medical University School of Medicine, Department of Physiology, Associate Professor, 医学部, 助教授 (40209664)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Suguru  Sapporo Medical University School of Medicine, Department of Physiology, Assistant, 医学部, 助手 (50325867)
Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsRabbit / Hopping movement / Locomotion / Decerebration / Locomotor region / Brainstem / Spinal cord / Descending pathway
Research Abstract

This study aimed to investigate the neural mechanisms of the control of hopping movements in rabbits. Under halothane anesthesia, male rabbits (2-3 kg) were surgically decerebrated at the precollicular-postmammillary level. The head was then fixed in a stereotaxic apparatus, and the abdominal part was supported by rubber belts. Wood's-metal-filled glass microelectrodes were inserted into the midbrain and electrical stimuli (50 Hz, 10-100 μA, 0.2 ms duration) were applied systematically for 5-15 sec at every 0.5 mm. Stimulus sites for evoking hindlimb hopping were found in the cuneiform nucleus in the midbrain, which corresponds to the mesencephalic locomotor region in cats. During the effective midbrain stimulation, the left and right hindlimbs always exhibited rhythmic movements in phase, not alternately as usually seen in cats' locomotion. Stronger stimuli increased the locomotor cycle frequency and prolonged the emerging period of locomotion. This suggests that although cats and rab … More bits have similar locomotion-inducing sites at the supraspinal level, the neural systems for generating their specific locomotor patterns are organized in a different manner in the spinal cord. After the right spinal cord hemisection at Th11-12, the left or right midbrain stimulation evoked rhythmic movements in the left hindlimb, but no or very weak movements in the right hindlimb. After transection of the bilateral medial longitudinal fasciculus by inserting a thin plastic blade (4 mm wide) into the medulla, the midbrain stimuli at high intensity could still evoke hopping movements. After insertion of a 7 mm-wide blade, however, the stimuli could no longer evoke such movements. These findings suggest that spinal neural circuits for generating in phase left-right hindlimb hopping movements need to receive synchronized bilateral descending inputs from the brainstem, and that the pathways descending in the lateral portion of the reticular formation may function as an important system which mediates locomotor command signals from supraspinal centers to the spinal cord in rabbits. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (53 results)

All 2006 2005 2004 2003 Other

All Journal Article (46 results) Patent(Industrial Property Rights) (2 results) Publications (5 results)

  • [Journal Article] Characteristics of fore- and hindlimb movements during the midbrain stimulus-evoked locomotion in decerebrated rabbits.2006

    • Author(s)
      Matsuyama K, Kobayashi S, Ishiguro M, Aoki M
    • Journal Title

      Journal of Physiological Sciences 56(Suppl)

    • NAID

      130005448521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Projection patterns of lamina VIII commissural neurons in the lumbar spinal cord of the adult cat : an anterograde neural tracing study.2006

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Newroscience (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Projection patterns of lamina VIII commissural neurons in the lumbar spinal cord of the adult cat : an anterograde neural tracing study.2006

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neuroscience (Article in Press)(Available online 13 March 2006, DOI:10.1016/j.neuroscience.2006.02.005)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of fore- and hindlimb movements during the midbrain stimulus-evoked locomotion in decerebrated rabbits.2006

    • Author(s)
      Matsuyama K, Ishiguro M, Kobayashi S, Aoki M.
    • Journal Title

      J Physiol Sci 56(Suppl)

    • NAID

      130005448521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Projection patterns of lamina VIII commissural neurons in the lumbar spinal cord of the adult cat : an anterograde neural tracing study.2006

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neuroscience (印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Relative contribution of Ia inhibitory interneurons to inhibition of feline contralateral motoneurons evoked via commissural interneurons.2005

    • Author(s)
      Jankowska E, Krutki P, Matsuyama K.
    • Journal Title

      Journal of Physiology 568

      Pages: 617-628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Annual Research Report 2005 Final Research Report Summary
  • [Journal Article] Comparison of midazolam effects on inhibitory postsynaptic currents in hippocampal CA3 with those in CA1.2005

    • Author(s)
      Kobayashi S et al.
    • Journal Title

      NeuroReport 16

      Pages: 1003-1007

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific intraspinal projection patterns of lumbar commissural axons in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Japanese Journal of Physiology 55(Suppl)

    • NAID

      130005447699

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of the reticulospinal pathways in generation of hopping movements in rabbits.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neuroscience Research 52(Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 除脳ウサギにおける後肢跳躍誘発部位の同定と誘発運動パターンの特徴2005

    • Author(s)
      松山清治, 小林 卓, 青木 藩
    • Journal Title

      日本生理学雑誌 67(3)

      Pages: 125-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Locomotor roles of the reticulospinal pathways in the control of hindlimb hopping movements in rabbits in comparison with locomotion in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Ishiguro M, Aoki M
    • Journal Title

      Abstract of 35th Annual Meeting of Society for Neuroscience Abstract Viewer

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] ウサギ後肢跳躍運動の発現・制御に関わる脳幹-脊髄神経機構2005

    • Author(s)
      松山清治, 小林 卓, 石黒雅敬, 青木 藩
    • Journal Title

      日本生理学雑誌 67(12)

      Pages: 401-401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Relative contribution of Ia inhibitory interneurones to inhibition of feline contralateral motoneurones evoked via commissural interneurones.2005

    • Author(s)
      Jankowska E, Krutki P, Matsuyama K.
    • Journal Title

      J Physiol 568

      Pages: 617-628

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Comparison of midazolam effects on inhibitory postsynaptic currents in hippocampal CA3 with those in CA1.2005

    • Author(s)
      Kobayashi S, Fujito Y, Matsuyama K, Aoki M.
    • Journal Title

      NeuroReport 16

      Pages: 1003-1007

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific intraspinal projection patterns of lumbar commissural axons in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Jpn J Physiol 55(Suppl)

    • NAID

      130005447699

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Role of the reticulospinal pathways in generation of hopping movements in rabbits.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neurosci Res 52(Suppl)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Locomotor roles of the reticulospinal pathways in the control of hindlimb hopping movements in rabbits in comparison with locomotion in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Ishiguro M, Aoki M.
    • Journal Title

      Abstract of 35th Annual Meeting of the Society for Neuroscience

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Specific intraspinal projection patterns of lumbar commissural axons in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Japanese Journal of Physiology 55 Suppl

    • NAID

      130005447699

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of the reticulospinal pathways in generation of hopping movements in rabbits.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neuroscience Research 52 Suppl

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Locomotor roles of the reticulospinal pathways in the control of hindlimb hopping movements in rabbits in comparison with locomotion in cats.2005

    • Author(s)
      Matsuyama K, Kobayashi S, Ishiguro M, Aoki M.
    • Journal Title

      Abstract of 35th Annual Meeting of Society for Neuroscience Abstract Viewer

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Coupling between feline cerebellum (fastigial neurons) and motone urons innervating hindlimb muscles2004

    • Author(s)
      Matsuyama K, Jankowska K
    • Journal Title

      Journal of Neurophysiology 91

      Pages: 1183-1192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lumbar commissural interneurons with reticulospinal inputs in the cat : morphology and discharge patterns during fictive locomotion2004

    • Author(s)
      Matsuyama K et al.
    • Journal Title

      Journal of Comparative Neurology 474

      Pages: 546-561

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary 2004 Annual Research Report
  • [Journal Article] Locomotor role of the corticoreticular-reticulospinal-spinal interneuronal system2004

    • Author(s)
      Matsuyama K et al.
    • Journal Title

      Progress in Brain Research 143

      Pages: 239-249

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biomechanical constraints in hindlimb joints during the quadrupedal versus bipedal locomotion of M. Fuscata.2004

    • Author(s)
      Nakajima K et al.
    • Journal Title

      Progress in Brain Research 143

      Pages: 183-190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Integration of multiple motor segments for the elaboration of locomotion : role of the fastigial nucleus of the cerebellum.2004

    • Author(s)
      Mori S, Nakajima K, Mori F, Matsuyama K.
    • Journal Title

      Progress in Brain Research 143

      Pages: 341-351

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential effects of Midazolam on inhibitory postsynaptic currents in CA1 pyramidal cells and dentate gyrus granule cells of rat hippocampal slices.2004

    • Author(s)
      Kobayashi S et al.
    • Journal Title

      Brain Research 1003

      Pages: 176-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] 歩行運動の発現・制御に関わる脳幹-脊髄神経機構-網様体脊髄路-脊髄交連細胞機構の機能的役割-.2004

    • Author(s)
      松山清治, 小林 卓, 青木 藩
    • Journal Title

      札幌医学雑誌 73

      Pages: 19-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of supraspinal hopping movement -inducing sites in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Japanese Journal of Physiology 54(Suppl)

    • NAID

      130007038659

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Locomotor patterns evoked by stimulation of supraspinal locomotion-inducing sites in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neuroscience Research 50(Suppl)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of locomotor movements evoked by stimulation of the midbrain locomotion-inducing site in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Abstract of 34th Annual Meeting of the Society for Neuroscience Abstract Viewer

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Coupling between feline cerebellum (fastigial neurons) and motoneurons innervating hindlimb muscles.2004

    • Author(s)
      Matsuyama K, Jankowska K.
    • Journal Title

      J Neurophysiol 91

      Pages: 1183-1192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Cover figure2004

    • Author(s)
      Matsuyama K, Jankowska K.
    • Journal Title

      J Neurophysiol Vol 91, March issue

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Lumbar commissural interneurons with reticulospinal inputs in the cat : morphology and discharge patterns during fictive locomotion.2004

    • Author(s)
      Matsuyama K, Nakajima K, Mori F, Aoki M, Mori S.
    • Journal Title

      J Comp Neurol 474

      Pages: 546-561

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Locomotor role of the corticoreticular-reticulospinal-spinal interneuronal system.2004

    • Author(s)
      Matsuyama K, Mori F, Nakajima K, Drew T, Aoki M, Mori S.
    • Journal Title

      Prog Brain Res 143

      Pages: 239-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Biomechanical constraints in hindlimb joints during the quadrupedal versus bipedal locomotion of M. fuscata.2004

    • Author(s)
      Nakajima K, Mori F, Takasu C, Mori M, Matsuyama K, Mori S.
    • Journal Title

      Prog Brain Res 143

      Pages: 183-190

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Integration of multiple motor segments for the elaboration of locomotion : role of the fastigial nucleus of the cerebellum.2004

    • Author(s)
      Mori S, Nakajima K, Mori. F, Matsuyama K.
    • Journal Title

      Prog Brain Res 143

      Pages: 341-351

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Differential effects of Midazolam on inhibitory postsynaptic currents in CA1 pyramidal cells and dentate gyrus granule cells of rat hippocampal slices.2004

    • Author(s)
      Kobayashi S, Fujito Y, Matsuyama K, Aoki M.
    • Journal Title

      Brain Res 1003

      Pages: 176-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of supraspinal hopping movement-inducing sites in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Jpn J Physiol 54(Suppl)

    • NAID

      130007038659

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Locomotor patterns evoked by stimulation of supraspinal locomotion-inducing sites in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Neurosci Res 50(Suppl 1)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Characteristics of locomotor movements evoked by stimulation of the midbrain locomotion-inducing site in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K, Kobayashi S, Aoki M.
    • Journal Title

      Abstract of 34th Annual Meeting of the Society for Neuroscience

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Identification of supraspinal hopping movement-inducing sites in decerebrate rabbits2004

    • Author(s)
      Matsuyama K et al.
    • Journal Title

      Japanese Journal of Physiology 54

    • NAID

      130007038659

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Locomotor patterns evoked by stimulation of supraspinal locomotion-inducing sites in decerebrate rabbits.2004

    • Author(s)
      Matsuyama K.et al.
    • Journal Title

      Neuroscience Research 50

    • Related Report
      2004 Annual Research Report
  • [Journal Article] 歩行運動の発現・制御に関わる脳幹-脊髄神経機構-網様体脊髄路-脊髄交連細胞機構の機能的役割-2004

    • Author(s)
      松山清治, 小林 卓, 青木 藩
    • Journal Title

      札幌医学雑誌 73

      Pages: 19-25

    • Related Report
      2004 Annual Research Report
  • [Journal Article] ネコの歩行リズム生成・制御機構の構築と機能的特徴.2003

    • Author(s)
      松山清治, 青木 藩
    • Journal Title

      生体医工学 42(Suppl1)

      Pages: 158-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Ascending and descending brainstem neuronal activity during cystometry in decerebrate cats.2003

    • Author(s)
      Sugaya K, Ogawa Y, Hatano T, Nishijima S, Matsuyama K, Mori S.
    • Journal Title

      Neurol Urodyn 22

      Pages: 343-350

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Coupling between fastigial neurons and feline hindlimb motoneurons2003

    • Author(s)
      Matsuyama K, Jankowska E.
    • Journal Title

      Neurosci Res 46(Suppl)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 猫繁殖用飼育ケージ2005

    • Inventor(s)
      松山清治
    • Industrial Property Rights Holder
      北海道
    • Filing Date
      2005-12-22
    • Acquisition Date
      2006-02-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 猫繁殖用飼育ケージ2005

    • Inventor(s)
      松山 清治
    • Industrial Property Rights Holder
      北海道
    • Filing Date
      2005-12-22
    • Acquisition Date
      2006-02-15
    • Related Report
      2005 Annual Research Report
  • [Publications] Matsuyama K, Jankowska K: "Coupling between feline cerebellum (fastigial neurons) and motoneurons innervating hindlimb muscles"Journal of Neurophysiology. 91・3. 1183-1192 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuyama K et al.: "Lumbar commissural interneurons with reticulospinal inputs in the cat : morphology and discharge patterns during fictive locomotion"Journal of Comparative Neurology. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuyama K et al.: "Locomotor role of the corticoreticular-reticulospinal-spinal interneuronal system"Progress in Brain Research. 143. 239-249 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kobayashi S et al.: "Differential effects of Midazolam on inhibitory postsynaptic currents in CA1 pyramidal cells and dentate gyrus granule cells of rat hippocampal slices"Brain Research. 1003. 176-182 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuyama K et al.: "Identification of supraspinal hopping movement-inducing sites in decerebrate rabbits"Japanese Journal of Physiology. (印刷中). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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