| Project/Area Number |
15500305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
SUTO Jun-ichi National Institute of Agrobiological Sciences, Department of Molecular Biology and Immunology, Senior Researcher, 動物科学研究領域・生殖機構研究ユニット, 主任研究員 (60355740)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Dh (Dominant hemimelia) / growth retardation / neonatal lethality / Multigenic trait / X chromosome / Y chromosome / Y consomic strains / testis weight / 致死症 / Y染色体コンソミックマウス / DDD / 新生仔成長傷害・致死 / X染色体(Grdhq1) / 多因子性疾患 |
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| Research Abstract |
Most F_1-Dh/+ males, crosses between inbred DDD strain females and DH-Dh/+ strain males, die during the neonatal period. Affected F_1-Dh/+ males exhibit a typical symptom of growth retardation, with problems of urination and defecation. This is caused by a rectovesical fistula formed between the rectum and the urinary bladder in conjunction with an imperforate anus. The lethal phenotype does not occur in the reciprocal cross between DH-Dh/+ females and DDD males. Genetic mapping analysis of the loci underlying the lethality has revealed that the lethality is a consequence of synergism among three independent gene loci; that is, the DH allele at Dh locus on Chr 1, the DDD allele at the Grdhq1 locus on the X Chr, and a putative Y-linked locus in some inbred strains. By establishing Y chromosome consomic strains, I proved the commitment of Y-linked gene(s). During the course of the study, I noticed that Dh has effects on male fertility, and obtained some preliminary results that Dh may interacts with more than one Y-linked genes.
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