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Analysis of the mechanism of a defensive response newly found in skin epidermis to the mutagenic effect of UV.

Research Project

Project/Area Number 15510040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTohoku University

Principal Investigator

IKEHATA Hironobu  Tohoku University, Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (90250737)

Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2004: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordsmutation / UV / skin / transgenic mouse / skin cancer / stratospheric ozone layer
Research Abstract

We have found a biological response of mammalian skin to UVB that the dose-dependent mutation induction in mouse skin epidermis is suppressed at high dose range, the response that we call the mutation induction suppression (MIS). MIS response is thought to be a tissue-specific biological response that could not be deduced from cellular-level in vitro studies, and could be mediated through cell exclusion mechanisms of genomically damaged cells like apoptosis or immunological cell killing. To clarify the mechanism of MIS response, we studied the apoptotic and immunological inflammation responses in skin epidermis to UVB. However, our histological analyses have not been successful methodologically. We also performed a genetical analysis with a p53 gene-knockout mouse, and found that the p53-dependent apoptosis pathway would not contribute to MIS response.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (8 results)

All 2004 2003 Other

All Journal Article (6 results) Publications (2 results)

  • [Journal Article] Mutation spectrum in sunlight-exposed skin epidermis : small but appreciable contribution of oxidative stress-induced mutagenesis.2004

    • Author(s)
      Hironobu Ikehata
    • Journal Title

      Mutation Research 556

      Pages: 11-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Mutation spectrum in sunlight-exposed skin epidermis : small but appreciable contribution of oxidative stress-induced mutagenesis.2004

    • Author(s)
      Ikehata, H., S.Nakamura, T.Asamura, T.Ono
    • Journal Title

      Mutat.Res. 556

      Pages: 11-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] UVA induces C -> T transitions at methyl CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.2003

    • Author(s)
      Hironobu Ikehata
    • Journal Title

      Mutagenesis 18

      Pages: 511-519

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of mutation spectrum in UVB-exposed mouse skin epidermis and dermis : frequent occurrence of C -> T transition at methylated CpG-associated dipyrimidine sites.2003

    • Author(s)
      Hironobu Ikehata
    • Journal Title

      Environmental and Molecular Mutagenesis 41

      Pages: 280-292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] UVA induces C → T transitions at methyl CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.2003

    • Author(s)
      Ikehata, H., H.Kudo, T.Masuda, T.Ono
    • Journal Title

      Mutagenesis 18

      Pages: 511-519

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of mutation spectra in UVB-exposed mouse skin epidermis and dermis : frequent occurrence of C → T transition at methylated CpG-associated dipyrimidine sites.2003

    • Author(s)
      Ikehata, H., T.Masuda, H.Sakata, T.Ono
    • Journal Title

      Environ.Mol.Mutagen. 41

      Pages: 280-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Publications] Hironobu Ikehata: "Analysis of mutation spectrum in UVB-exposed mouse skin epidermis and dermis : frequent occurrence of C-> T transition at methylated CpG-associated dipyrimidine sites"Environmental and Molecular Mutagenesis. 41. 280-292 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hironobu Ikehata: "UVA induces C -> T transitions at methyl CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB"Mutagenesis. 18. 511-519 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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