| Co-Investigator(Kenkyū-buntansha) |
MORI Kenji Tokushima University, Hospital of School of Medicine and Dentistry, Lecturer, 医学部歯学部附属病院, 講師 (20274201)
HARADA Masafumi Tokushima University, School of Medicine, Professor, 医学部, 教授 (20228654)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2004: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Research Abstract |
Autism shows disorders of sociability, communication and imagination. From this, a social rule, the tacit comprehension which are not stipulated in particular, and grasp of an ethical and moral matter are difficult to understand. Furthermore, it is reported that autistic patients develop various troubles in behavioral disorder by school life and everyday life and delinquency.
We demanded subjects to judge whether a scene of a morality as a image was good or bad, and we used fMRI and measured brain activity of stage of the information processing. The control task was a meaningless image. As an experimental paradigm, we used a box-car design involving activation task of 45 seconds and control task of 45 seconds. A construction of task was 3 minutes for one series. Subjects were asked to press button with their right hand as soon as possible when they judged. A subject consisted of seven boys with high functioning autism (age fron 11 years to 17 years old), three normal boys (13 years old)
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, seven normal adults, one non-autistic and epileptic boy (normal IQ) and one normal IQ and non-autistic boy with Sotos syndrome. We explained it to subjects and/or their guardians on the occasion of examination enough and obtained informed consent from all subjects.
A physically unimpaired person revealed active enhancement in the temporo- parieto- occipital border region 〜 middle of temporal lobe (the left>right), and the bilateral dorsolateral and anterior medial frontal lobe. High functioning autism boy revealed activity in a dorsal and ventral frontal lobe (the left<right), the anterior medial frontal lobe, and the temporo- parieto- occipital border region 〜 anterior temporal lobe (the left<right). In addition, it revealed activity in the left precentral gyrus, and the right ventral and medial frontal lobe. Rate of correct answer to task did not have the difference among autism and controls.
A correct answer rate of a task did not have a difference, accordingly it is assumed that task contents were brief as for this. Moreover, we understand it how emotional influence should act for varying thing. Autism in a real scene and such a problem debt reveal the detachment phenomenon which they cannot adopt the action that they should really adopt but they know a matter as knowledge. Thus it is thought that a difference did not appear between autism and controls.
That system of task processing is different from a physically unimpaired person is assumed for autism by results of fMRI, but we need to increase number of experiment and require what we devise a problem and review more. Less
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