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Interaction between cholesterol-bearing amphiphilic polyelectrolytes and surfactants

Research Project

Project/Area Number 15550112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer chemistry
Research InstitutionFaculty of Engineering, Fukui University

Principal Investigator

MORISHIMA Yotaro  Fukui University, Faculty of Engineering, Professor, 工学部, 教授 (70028249)

Co-Investigator(Kenkyū-buntansha) YUSA Shin-ichi  University of Hyogo, Department of Materials and Science, Research assistant, 大学院・工学研究科, 助手 (00301432)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥800,000 (Direct Cost: ¥800,000)
KeywordsAmphiphilic Polyelectrolyte / Cholesteryl group / Bile acid / Aggregation / Hydrophobic interaction / Nonionic surfactant / Micelle / Fluorescence
Research Abstract

A hydrophobically modified polysulfonate bearing a small mole percent (5 mol %) of cholesteryl moieties forms an intermolecularly bridged flower micelle in water, arising from intermolecular associations of the polymer-bound cholesteryl groups. Binding of sodium cholate (SC) to this polymer micelle in water was investigated using ^1H NMR spin-spin relaxation time, static light scattering, quasi-elastic light scattering, and fluorescence techniques. The intermolecular association of the polymer-bound cholesteryl groups was disrupted, to some extent, by the addition of SC, resulting in the formation of complexes of the polymer-bound cholesteryl groups and SC. To investigate interactions between the polymer-bound cholesteryl groups and SC, the cholesteryl groups were labeled with a naphthalene moiety. Fluorescence spectra of the naphthalene labels and NMR spin-spin relaxation time data suggested that interactions between the aggregates of the polymer-bound cholesteryl groups and SC occurred below a critical micelle concentration of SC in water.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (23 results)

All 2005 2004 2003 Other

All Journal Article (22 results) Book (1 results)

  • [Journal Article] Conformational effects on the performance and selectivity of a polymeric pseudostationary phase in electrokinetic chromatography2005

    • Author(s)
      Jonathan P.McCarney
    • Journal Title

      Electrophoresis 26

      Pages: 841-848

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synthesis of Well-Defined Amphiphilic Block Copolymers Having Phospholipid Polymer Sequences as a Novel Biocompatible Polymer Micelle Reagent2005

    • Author(s)
      Shin-ichi Yusa
    • Journal Title

      Biomacromolecules 6

      Pages: 663-670

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure-Selective Dye Uptake into an Aggregate of a Copolymer with Linear Polyelectrolyte Block and Hydrophobic Block Carrying Pendant Dendritic Moiety in Water2005

    • Author(s)
      Kana Tamano
    • Journal Title

      J.Phys.Chem.B 109

      Pages: 1226-1230

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 可逆的付加-開裂連鎖移動(RAFT型)リビングラジカル重合によるカチオン性ブロック共重合体の構築2005

    • Author(s)
      遊佐 真一
    • Journal Title

      高分子加工 54

      Pages: 153-159

    • NAID

      40006720742

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Conformational effects on the performance and selectivity of a polymeric pseudostationary phase in electrokinetic chromatography2005

    • Author(s)
      Jonathan P.McCarney, Robert D.Loflin, Erika Rauk, Shin-ichi Yusa, Christopher P.Palmer
    • Journal Title

      Electrophoresis 26

      Pages: 841-848

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Synthesis of Well-Defined Amphiphilic Block Copolymers Having Phospholipid Polymer Sequences as a Novel Biocompatible Polymer Micelle Reagent2005

    • Author(s)
      Shin-ichi Yusa, Kenichi Fukuda, Tohei Yamamoto, Kazuhiko Ishihara, Yotaro Morishima
    • Journal Title

      Biomacromolecules 6

      Pages: 663-670

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Structure-Selective Dye Uptake into an Aggregate of a Copolymer with Linear Polyelectrolyte Block and Hydrophobic Block Carrying Pendant Dendritic Moiety in Water2005

    • Author(s)
      Kana Tamano, Toyoko Imae, Shin-ichi Yusa, Yoshihiko Shimada
    • Journal Title

      J.Phys.Chem.B. 109

      Pages: 1226-1230

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Heat-induced Association and Dissociation Behavior of Amphiphilic Diblock Copolymer Synthesized via Reversible Addition-Fragmentation Chain Transfer Radical Polymerization2004

    • Author(s)
      Shin-ichi Yusa
    • Journal Title

      Macromolecules 37

      Pages: 7507-7513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] pH変化をトリガーとする単一高分子ミセルの形成と崩壊2004

    • Author(s)
      遊佐 真一
    • Journal Title

      高分子論文集 61

      Pages: 399-407

    • NAID

      10013468784

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Heat-Induced Association and Dissociation Behavior of Amphiphilic Diblock Copolymer Synthesized via Reversible Addition-Fragmentation Chain Transfer Radical Polymerization2004

    • Author(s)
      Shin-ichi Yusa, Yoshihiko Shimada, Yoshiro Mitsukami, Tohei Yamamoto, Yotaro
    • Journal Title

      Macromolecules 37

      Pages: 7507-7513

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] pH-Responsive Micellization of Amphiphilic Diblock Copolymers Synthesized via Reversible Addition-Fragmentation Chain Transfer Polymerization2003

    • Author(s)
      Shin-ichi Yusa
    • Journal Title

      Macromolecules 36

      Pages: 4208-4215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fluorescence Studies of Associative Behavior of Cationic Surfactant Moieties Covalently Linked to Poly(acrylamide) at the Surfactant Head or Tail2003

    • Author(s)
      Hiromi Morimoto
    • Journal Title

      Polymer 44

      Pages: 943-952

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 側鎖にスルホネート基とカルボキシレート基を含むpH応答性単一高分子ミセルの構築2003

    • Author(s)
      遊佐 真一
    • Journal Title

      高分子加工 52

      Pages: 209-214

    • NAID

      40005760618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] pH-Responsive Micellization of Amphiphilic Diblock Copolymers Synthesized via Reversible Addition-Fragmentation Chain Transfer Polymerization2003

    • Author(s)
      Shin-ichi Yusa, Yoshihiko Shimada, Yoshiro Mitsukami, Tohei Yamamoto, Yotaro Morishima
    • Journal Title

      Macromolecules 36

      Pages: 4208-4215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Fluorescence Studies of Associative Behavior of Cationic Surfactant Moieties Covalently Linked to Poly(acrylamide) at the Surfactant Head or Tail2003

    • Author(s)
      Hiromi Morimoto, Akihito Hashidzume, Yotaro Morishima
    • Journal Title

      Polymer 44, (2)

      Pages: 943-952

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] pH-Responsive Micellization of Amine-Containing Cationic Diblock Copolymers Prepared by Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization

    • Author(s)
      Shin-ichi Yusa
    • Journal Title

      Polymer Journal (印刷中)

    • NAID

      10020515389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Binding of Bile Salts to an Amphiphilic Polysulfonate Modified with Cholesterol Moieties

    • Author(s)
      Shin-ichi Yusa
    • Journal Title

      Polymer Journal (印刷中)

    • NAID

      10019037952

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 両親媒性高分子電解質の会合構造と溶液物性

    • Author(s)
      遊佐 真一
    • Journal Title

      オレオサイエンス (印刷中)

    • NAID

      130004853476

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amphiphilic Polyelectrolytes : Characterization of Associative Properties and Self-Assembled Nanostructures in Water

    • Author(s)
      Yotaro Morishima
    • Journal Title

      ACS Symposium Series (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] pH-Responsive Micellization of Amine-Containing Cationic Diblock Copolymers Prepared by Reversible Addition-Fragmentation Chain Transfer (RAFT) Radical Polymerization

    • Author(s)
      Shin-ichi Yusa, Yoshitane Konishi, Yoshiro Mitsukami, Tohei Yamamoto, Yotaro Morishima
    • Journal Title

      Polym.J. (in press.)

    • NAID

      10020515389

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Binding of Bile Salts to an Amphiphilic Polysulfonate Modified with Cholesterol Moieties

    • Author(s)
      Shin-ichi Yusa, Kasumi Ikeda, Tohei Yamamoto, Yotaro Morishima
    • Journal Title

      Polym.J. (in press.)

    • NAID

      10019037952

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Amphiphilic Polyelectrolytes : Characterization of Associative Properties and Self-Assembled Nanostructures in Water

    • Author(s)
      Yotaro Morishima
    • Journal Title

      ACS Symposium Series (in press.)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Book] 実験化学講座262005

    • Author(s)
      遊佐 真一
    • Total Pages
      5
    • Publisher
      丸善
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary

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Published: 2003-04-01   Modified: 2016-04-21  

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