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Study for the mechanism of concerted evolution at the Drosophila histone genes

Research Project

Project/Area Number 15570186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUO Yoshinori  The University of Tokushima, Faculty of Integrated Arts and Sciences, Professor, 総合科学部, 教授 (80219401)

Project Period (FY) 2003 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2004: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsDrosophila / histone gene / concerted evolution / GC content / natural selection / population size / ゲノム進化 / 突然変異 / コドン使用 / 多重遺伝子
Research Abstract

To elucidate the mechanism of concerted evolution, the evolutionary changes occurred in the Drosophila histone genes have been unveiled. The factors affecting for the concerted evolution were estimated. The repeating units of histone gene in Drosophila were studied for 6 sibling species of D.melanogaster (D.teissieri, D.sechellia, D.mauritiana, D.yakuba, D.orena, and D.erecta) and 5 other species (D.americana, D.lutescens, D.pseudoobscura, D.takahashii, and D.immigrans). In addition, the genetic heterogeneity among the repeating units at the nucleotide sequence level was studied for several species. It was less than 1% and much smaller than the difference between the closely related species. This suggested that the concerted evolution have been observed not only in the H3 gene region but also in the whole repeating unit. Comparison analysis of the GC content in the coding region, 5'-region, 3'-region, and spacer region indicated that no significant difference was observed in the 3'-region and spacer region in where mutation bias was expected more efficiently. In contrast, the species difference was observed in the GC content at the 3^<rd> codon with the same tendency for all histone genes. These results indicated that the natural selection is playing a more important role than the mutation bias. Natural selection against A and T at the GC rich codon was expected, and the efficiency for it depends on the population size. The observed species difference in the GC content can be explained by the different history of the population of the species. This kind of natural selection explains the part of the concerted evolution.

Report

(5 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (10 results)

All 2007 2005 2003 Other

All Journal Article (8 results) Publications (2 results)

  • [Journal Article] Genomic structure and evolution of the histone gene family in Drosophila2007

    • Author(s)
      Matsuo, Y.
    • Journal Title

      Current Topics in Genetics (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Molecular characterization and evolution of the repeating units of histone genes in Drosophila americana : coexistence of quartet and quintet units in a genome2005

    • Author(s)
      Nagoda, N. et al.
    • Journal Title

      Insect Molecular Biology 14/6

      Pages: 713-717

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular characterization and evolution of the repeating units of histone genes in Drosophila americana : coexistence of quartet and quintet units in a genome2005

    • Author(s)
      Nagoda, N.et al.
    • Journal Title

      Insect Molecular Biology 14/6

      Pages: 713-717

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular characterization and evolution of the repeating units of histone genes in Drosophila americana : coexistence of quartet and quintet units in a genome2005

    • Author(s)
      Nagoda, N, et al.
    • Journal Title

      Insect Molecular Biology 14/6

      Pages: 713-717

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Evolution of the GC content of the histone 3 gene in seven Drosophila species2003

    • Author(s)
      Matsuo, Y.
    • Journal Title

      Genes Genet. Syst. 78

      Pages: 309-318

    • NAID

      10012456658

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Divergence and heterogeneity of the histone gene repeating units in the Drosophila melanogaster species subgroup2003

    • Author(s)
      Kakita, M. et al.
    • Journal Title

      Genes Genet. Syst. 78

      Pages: 383-389

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Evolution of the GC content of the histone 3 gene in seven Drosophila species2003

    • Author(s)
      Matsuo, Y.
    • Journal Title

      Genes Genet.Syst. 78

      Pages: 309-318

    • NAID

      10012456658

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Divergence and heterogeneity of the histone gene repeating units in the Drosophila melanogaster species subgroup2003

    • Author(s)
      Kakita, M.et al.
    • Journal Title

      Genes Genet.Syst. 78

      Pages: 383-389

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Publications] Y.Matsuo: "Evolution of the GC content of the histone3 gene in seven Drosophila species"Genes Genet. Syst.. 78. 309-318 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Kakita et al.: "Divergence and heterogeneity of the histone gene repeating units in the Drosophila melanogaster specles subgroup"Genes Genet. Syst.. 78. 383-389 (2003)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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