Development of a novel sugar linkage and sugar-related bioactive compounds
| Project/Area Number |
15590023
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
TAKAHASHI Hideyo Teikyo University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (10266348)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAMME Rie Teikyo University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (70349257)
|
|---|
| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
|
|---|
| Keywords | Coyolosa / ether-linked sugar / ether bonding / reductive etherification / hypogelycemic activit / coyolosa |
|---|
| Research Abstract |
Coyolosa, a new natural product isolated from the Acrocomia mexicana root, has shown a significant effect on fasting blood glucose levels. While there can be no doubt that Coyolosa has a structure with two pyranoses linked at each of their 6-positions, it is less obvious that the stereochemistry of its pyranose moiety corresponds to the proposed structure. In this communication, we report a novel synthesis of 6, 6'-ether-connected pyranoses. Also, we reconsidered the stereochemistry of the proposed structure of Coyolosa based on the structure-activity relationships (SAR) studies. This is the first synthesis of ether-connected sugar based on an acetalization-reduction procedure.
|
Report
(3 results)
Research Products
(6 results)
