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Theoretical design of taste masking for amino acid or basic drugs using a taste sensor

Research Project

Project/Area Number15590146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionMukogawa Women's University

Principal Investigator

UCHIDA Takahiro  Mukogawa Women's University, Department of Pharmaceutical Sciences, Professor, 薬学部, 教授 (70203536)

Co-Investigator(Kenkyū-buntansha) MIYANAGA Yohko  Mukogawa Women's University, Department of Pharmaceutical Sciences, Assistant, 薬学部, 助手 (10360265)
IKEZAKI Hidekazu  Intelligent Sensor Technology, Inc., Chief researcher, 主席研究員
Project Period (FY) 2003 – 2004
Project Status Completed(Fiscal Year 2004)
Budget Amount *help
¥3,000,000 (Direct Cost : ¥3,000,000)
Fiscal Year 2004 : ¥500,000 (Direct Cost : ¥500,000)
Fiscal Year 2003 : ¥2,500,000 (Direct Cost : ¥2,500,000)
Keywordstaste sensor / amino acid / branched-chain amino acids / dry syrup / bitterness / 医薬品 / 抗生剤 / 懸濁液
Research Abstract

The purpose of this study was to develop a quantitative prediction method for the determination of the bitterness of solutions containing amino acids or medicines using a multichannel taste sensor.
In related to amino acids, we focused on taste of elemental diets. We quantitively evaluate the bitterness of various concentrated of various type of amino acids such as BCAA : L-isoleucine, L-leucine, L-valine.
In related to palatability for them, intensities for various palatability scales were measured. The addition of flavors was so effective in reducing the bitterness intensities of BCAA solutions since organic acid was the most effective for reducing the bitterness. (reference No.1) Whereas the bitterness or saltiness was negatively correlated with total palatability (reference No.2).
The antibiotics which are basic medicines, taste, the bitterness of pediatric medicines were evaluated by sensor measurement. The predicted data was correlated with obtained value in gustatory sensation result and bitterness enhancement of dry syrup could be predicted by taste sensor usage (reference No.3).
In the case of commercial nutritive drinks which containing thiamine or herbal medicine ingredients, obtained value in human gustatory sensation could be predicted by taste sensor (reference No.4). Thus the usefulness of taste sensor was demonstrated in prediction of basic medicines or amino acids.

Report

(3results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report

Research Products

(15results)

All 2005 2004 Other

All Journal Article Publications

  • [Journal Article] 味覚センサを用いたマクロライド系ドライシロップの苦味評価(苦味マスキングに関する報告 第22報)2005

    • Author(s)
      辻 絵里子, 高田美幸, 内田享弘
    • Journal Title

      医療薬学 31・3

      Pages : 186-193

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Effective Bitterness Evaluation of Macrolide Dry Syrup Formulations by a Taste Sensor2005

    • Author(s)
      Eriko Tsuji et al.
    • Journal Title

      Jpn.J.Pharm.Health Care Sci. 31(3)

      Pages : 186-193

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] 味覚センサを用いたマクロライド系ドライシロップの苦味評価(苦味マスキングに関する報告第22報)2005

    • Author(s)
      辻 絵里子, 高田美幸, 内田享弘
    • Journal Title

      医療薬学 31・3

      Pages : 186-193

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Suppression of the Bitterness of Enteral Nutrients Using Increased Particle Sizes of Branched-Chain Amino Acids(BCAAs) and Various Flavours : a Taste Sensor Study2004

    • Author(s)
      Yohko Miyanaga et al.
    • Journal Title

      Chem.Pharm.Bull. 52・4

      Pages : 490-493

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative taste evaluation of total enteral nutrition products2004

    • Author(s)
      Junji Mukai et al.
    • Journal Title

      Chem.Pharm.Bull. 52・12

      Pages : 1416-1421

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Bitterness Evaluation of Medicines for Pediatric Use by a Taste Sensor2004

    • Author(s)
      Toshihiko Ishizaka et al.
    • Journal Title

      Chem.Pharm.Bull. 52・8

      Pages : 943-948

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Evaluation of bottled nutritive drinks using a taste sensor2004

    • Author(s)
      Masumi Kataoka et al.
    • Journal Title

      Int.J.Pharm. 279・7

      Pages : 107-114

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Suppression of the Bitterness of Enteral Nutrients Using Increased Particle Sizes of Branched-Chain Amino Acids(BCAAs) and Various Flavours : a Taste Sensor Study2004

    • Author(s)
      Yohko Miyanaga et al.
    • Journal Title

      Chem.Pharm.Bull. 52(4)

      Pages : 490-493

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative taste evaluation of total enteral nutrition products2004

    • Author(s)
      Junji Mukai et al.
    • Journal Title

      Chem.Pharm.Bull. 52(12)

      Pages : 1416-1421

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Bitterness Evaluation of Medicines for Pediatric Use by a Taste Sensor2004

    • Author(s)
      Toshihiko Ishizaka et al.
    • Journal Title

      Chem.Pharm.Bull. 52(8)

      Pages : 943-948

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Evaluation of bottled nutritive drinks using a taste sensor2004

    • Author(s)
      Masumi Kataoka et al.
    • Journal Title

      Int.J.Pharm. 279(7)

      Pages : 107-114

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Suppression of the Bitterness of Enteral Nutrients Using Increased Particle Sizes of Branched-Chain Amino Acids(BCAAs) and Various Flavours: aTaste Sensor Study2004

    • Author(s)
      Yohko Miyanaga et al.
    • Journal Title

      Chem.Pharm.Bull. 52・4

      Pages : 490-493

    • Related Report
      2004 Annual Research Report
  • [Publications] Takahiro Uchida et al.: "Evaluation of the bitterness of antibiotics using a taste sensor"J.Pharm.Pharmacol.. 55. 1479-1485 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Atsu Tnigake et al.: "The Bitterness Intensity of Clarithromycin Evaluated by a Taste Sensor"Chem.Pharm.Bull.. 51・11. 1241-1245 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yohko Miyanaga et al.: "Quantitative Prediction of the Bitterness Suppression of Elemental Diets by Various Flavors Using a Taste Sensor"Pharm.Res.. 20・12. 1932-1938 (2003)

    • Related Report
      2003 Annual Research Report

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Published : 2003-04-01   Modified : 2016-04-21  

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