Immunohistochemical and immunogenetic analysis of Lennert lymphoma
| Project/Area Number |
15590300
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
MORI Naoyoshi Nagoya University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90045732)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Yoriki Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 講師 (90303643)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2004: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
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| Keywords | Lennert lymphoma / cytotoxic T cell / epithelioid cell / hemophagocytic syndrome / DIC / cytotoxic protein / granzyme B / MIB-1 score / Lennert リンパ腫 / 細胞傷害性Tリンパ球 / Lennertリンパ腫 / 細胞傷害性Tリンパ腫 / TIA-1 / サイトカイン血症 / EBウイルス |
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| Research Abstract |
We studied three cases of Lennert's lymphoma showing aggressive clinical course. These cases were also accompanied by disseminated intravascular coagulation(DIC) or hemophagocytic syndrome(HPS). We also compared these cases with non-aggressive type of Lennert's lymphoma. Of the three cases we experienced, two had lymphoma cell involvement in the liver and two in the bone marrow. In one case, a lymph node biopsy revealed Lennert's lymphoma histologically, however, liver biopsy obtained several weeks later revealed high grade large cell cytotoxic T cell lymphoma. Three cases showed hemophagocytic syndrome and the one showed DIC. Most of them died within a year after diagnosis, the shortest being 1.5 months. Immunohistochemically, all cases exhibited CD8+,CD4-, granzyme B+, and TIA-1+, showing cytotoxic T cell phenotype. Two cases showed positive reactivity for EB virus in the lymphoma cells with in situ hybridization. We also compared these cases with eight cases of non-aggressive type of Lennert's lymphoma. Compared with the latter, our four cases had higher count of MIB-1 positive lymphoma cells. In conclusion, our current study revealed that some cases of Lennert's lymphoma share common features with high grade cytotoxic T cell lymphoma. This indicate that Lennert's lymphoma may be a part of the spectrum of cytotoxic T cell lymphoma.
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Report
(3 results)
Research Products
(14 results)
