| Project/Area Number |
15590508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HAMADA Hiromi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant Professor, 大学院・人間総合科学研究科, 講師 (60261799)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIKI Yutaka University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant Professor, 大学院・人間総合科学研究科, 講師 (90344887)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | preeclampsia / genetic epidermplogy / gene polymorphism / proteome analysis / Clusterin |
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| Research Abstract |
The purpose of this study was to detect genetic factor of preeclampsia and to construct of a new preventive strategy.
The genes associated with preeclampsia were researched using the analysis of gene polymorphism and proteome analysis. And, interaction between the environmental factor or life habit of the patients of preeclampsia and their genetic factor was analyzed.
As a result of this study, new associated gene with preeclampsia was not found out by the analysis of gene polymorphism. Clusterin associated with preeclampsia could be first detected by the proteomic technique. (Proteomics. 2004) Also, new finding of association between third nerve palsy and serous retinal detachment in preeclampsia was obtained. (Hypertension in Pregnancy, 2006) However, the new association between the environmental factor or life habit of the patients and the preeclampsia related gene polymorphisms detected by our group (Journal of Medical Genetics,1997;Journal of Human Genetics,2000;Thrombosis and Haemostasis,2001;Journal of Human Genetics,2002) was not found in this study of a small sample size.
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