An epidemiological study on associations between the concentration and origin of dioxins in human and lung cancer by histology
| Project/Area Number |
15590509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Niigata University |
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Principal Investigator |
NAKADAIRA Hirot Niigata University, Graduate School of Medical and Dental Sciences, Lecturer, 大学院・医歯学総合研究科, 講師 (40217758)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masaharu Niigata University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (40018693)
TAKAHASHI Yukio Niigata University, Faculty of Engineering, Professor, 工学部, 教授 (70134955)
KAJIHARA Hideo Niigata University, Graduate School of Science and Technology, Associate Professor, 大学院・自然科学研究科, 助教授 (70324001)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Lung cancer / Histology / Heavy Metals / Arsenic / Endocrine Disrupters / Dioxins |
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| Research Abstract |
Lung cancer is the leading cause of cancer mortality in Japan, and its incidence is growing. The most notorious risk factor of lung cancer is smoking. Smoking alone can not account for lung cancer, however. Adenocarcinoma is considered to be less related to smoking. It is hence necessary to investigate risk factors excepting tobacco.
We found the geographical clustering of lung cancer by histology in Niigata prefecture, and since then we have been paying attention to heavy metals, of which geographical distribution coincides with the lung cancer clustering, as possible risk factors. In addition, we have also pointed out severe environmental pollution by dioxins in the prefecture approximately 30 years ago. Dioxins are considered to act as carcinogenic promoters and the lung is one of the main target organs of dioxins.
The objective of the present study is to conduct a cross-sectional study by determining the concentrations of dioxins in fat tissue from lung cancer patients by histology and to assess the association with the exposure to heavy metals.
The target patients were all male in their 50's through 70's. They consisted of four adenocarcinoma patients and as many squamous cell carcinoma patients. Out of 138 isomers of dioxins, 30 isomers were measured. As the results, most of the concentrations of dioxins were higher for tobacco-related squamous cell carcinoma than for less tobacco-related adenocarcinoma. This finding made it difficult to conclude that dioxins are one of the potent risk factor of lung cancer next to smoking.
However, in the present study we could master the technique of dioxin analysis, which fact means that measurement of dioxin in human fat tissue would make forward from now on.
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Report
(3 results)
Research Products
(9 results)
