The roles of intestinal micro flora and it's metabolites, bile acids, and sulfated polysaccharides in the inflammatory bowel disease.
| Project/Area Number |
15590640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
ARAKI Yoshio Shiga University of Medical Science, Department of Internal Medicine, Assistant Professor, 医学部, 助手 (00346032)
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| Project Period (FY) |
2003 – 2004
|
| Project Status |
Completed (Fiscal Year 2004)
|
| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2003: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
|---|
| Keywords | bile acid / permeability / protein kinase C / sulfated polysaccharide / 炎症性腸疾患 / Clostridium butyricum |
|---|
| Research Abstract |
In the present study, we have made it clear that
1.bile acids increase the permeability of intestinal epithelium via the generation of reactive oxygen species, and the activation of intracellular signaling systems such as protein kinase C,
2.sulfated polysaccharides such as dextran sulfate sodium can be depolymerized in the gut lumen.
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Report
(3 results)
Research Products
(16 results)
