Primary biliary cirrhosis and estrogen-mediated regulation of CD4+CD25+ thymocyte differentiation.
| Project/Area Number |
15590657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kochi Medical School |
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Principal Investigator |
ONISHI Saburo Kochi medical School, Gastroenterology and Hepatology, Professor, 医学部, 教授 (60136380)
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji Kochi medical School, Molecular Genetics, Associated professor, 医学部, 助教授 (60145125)
AKISAWA Naoaki Kochi medical School, Gastroenterology and Hepatology, Research assistant, 医学部, 助手 (00322280)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | gender / estrogen / thymocyte / differentiation / 原発性胆汁性肝硬変 / CD25 / GVH |
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| Research Abstract |
Primary biliary cirrhosis is an autoimmune liver disease with chronic nonsupprative destructive cholangitis (CNSDC). Middle aged-female is most sensitive to this disease. In thymus of estrogen deficient mice, CD3+TCRbeta high thymocytes and CD4+CD25+thymocytes are decreased in number though CD4+CD8+CD25+thymocytes are increased in number. These characteristic pathological features in estrogen deficient mice results in an evident increase of autoreactive T cells in aged mice possibly due to impaired maturation process of FOX3+ T cell. Exogeneous administration of estrogen abrogates these characteristic changes completely. Organ culture of thymus derived from estrogen deficient mice is a potent method to investigate the role of estrogen in the differentiation and maturation of thymocytes in vitro.
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Report
(3 results)
Research Products
(22 results)
