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Prevenstion of aspiration pneumonia and Research of the clinical application by VR1 and CMR1 agonists.

Research Project

Project/Area Number 15590795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

EBIHARA Satoru  Tohoku University, Hospital, Research associate, 病院, 助手 (90323013)

Project Period (FY) 2003 – 2005
Project Status Completed (Fiscal Year 2005)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordscapsaicin / TRPV1 / troche / pneumonia / 温度 / CMR1 / 嚥下反射 / 咳反射 / 口腔ケア / テオフィリン
Research Abstract

Recurrent pneumonia in older people is due to silent aspiration caused by depressed swallowing and cough reflexes because of an insufficient release of substance P.Direct administration of capsaicin to the pharynx can improve the swallowing reflex in older people. However, whether the daily capsaicin supplementation affects those risk factors for recurrent aspiration bronchitis and pneumonia in older people has not been investigated. To determine whether oral capsaicin troche supplementation every meal upregulates the impairment of upper respiratory protective reflexes such as the swallowing reflex and the cough reflex. Randomized-controlled study with recruitment through nursing homes in Sendai, Japan from September 2002 to December 2003. Sixty-four participants in nursing homes aged mean 81.9 ± 1.0 year old with chronic physical status. Participants were randomly assigned to the program for the supplementation of capsaicin trochisci or placebo trochisci soon before every meal for 4 w … More eeks. Assessment of individual latency of the swallowing reflex (LTSR) and cough reflex sensitivity. Before the commencement of this study, there were no significant baseline differences in multiple parameters between the intervention group and control group. LTSR in participants in the intervention group was significantly shortened, compared with the control group (P<.05). The odds ratio (OR) of the shortening of the LTSR of more than 1 minute in the intervention group was 3.4 [95% confidence interval (CI), 1.1-10.4], compared with the control group (P=.03). Particularly, daily capsaicin supplementation significantly increased the ratio of LTSR reduction at 4 weeks after the study to baseline LTSR in the high risk group (baseline LTSR>6.0sec) compared with the low risk group (baseline LTSR<3.0sec) and the intermediate group (3.0sec<baseline LTSR<6.0sec)(P<.005). The participants whose cough reflex sensitivity showed a decrease of the cough reflex threshold was observed in 17 participants (52.1%) in the intervention group but in only 7 participants (21.9%) in the control group after this study (OR : 4.1, [95% CI : 1.4-12.2], P<.01). Daily capsaicin supplementation showed a significant improvement in upper protective respiratory reflexes, particularly in older people with a high risk for aspiration. Less

Report

(4 results)
  • 2005 Annual Research Report   Final Research Report Summary
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • Research Products

    (18 results)

All 2005 2004 Other

All Journal Article (16 results) Publications (2 results)

  • [Journal Article] Capsaicin troche for swallowing dysfunction in older people.2005

    • Author(s)
      海老原ら
    • Journal Title

      J Am Geriatr Soc, 53(5)

      Pages: 824-828

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medical treatments and cares for geriatric syndrome : new strategies leaned from frail elderly.2005

    • Author(s)
      久保ら
    • Journal Title

      Tohoku J Exp Med, 205

      Pages: 205-215

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Capsaicin troche for swallowing dysfunction in older people.2005

    • Author(s)
      Ebihara T, Takahashi H, Ebihara S, Okazaki T, Sasaki T, Watando A, Nemoto M, Sasaki H.
    • Journal Title

      J Am Geriatr Soc 53(5)

      Pages: 824-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Medical treatments and cares for geriatric syndrome : new strategies leaned from frail elderly.2005

    • Author(s)
      Kubo H, Nakayama K, Ebihara S, Sasaki H.
    • Journal Title

      Tohoku J Exp Med 205

      Pages: 205-215

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2005 Final Research Report Summary
  • [Journal Article] Capsaicin troche for swallowing dysfunction in older people2005

    • Author(s)
      Ebihara T, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 53(4)

      Pages: 824-828

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cigarette smoking, cough reflex, and respiratory tract infection2005

    • Author(s)
      Ebihara S, Ebihara T, et al.
    • Journal Title

      Archives if Internal Medicine 165

      Pages: 814-814

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Differential gait kinematics between fallers and non-fallers in community-dwelling elderly people2005

    • Author(s)
      Chiba H, Ebihara S, et al.
    • Journal Title

      Geriatrics and Gerontology International 5

      Pages: 127-134

    • NAID

      10017127861

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Medical treatments and cares for geriatric syndrome2005

    • Author(s)
      Kubo H, Ebihara S, et al.
    • Journal Title

      Tohoku Journal of the Experimental Medicine 205

      Pages: 205-215

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tiapride may accelerated lung cancer in the elderly2005

    • Author(s)
      Asada M, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 53

      Pages: 731-732

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Acarbose attenuates hypoglycemia from dumping syndrome, in an elderly man with gastrectomy2005

    • Author(s)
      Yamada M, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 53

      Pages: 358-359

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effect of temperature on swallowing reflex in elderly patients with aspiration pneumonia2004

    • Author(s)
      Watando A, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 52

      Pages: 2143-2144

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Oral care and cough reflex sensitivity in elderly nursing home patients2004

    • Author(s)
      Watando A, Ebihara S, et al
    • Journal Title

      Chest 126

      Pages: 1066-1070

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Theophylline-improved swallowing reflex in elderly nursing home patients2004

    • Author(s)
      Ebihara T, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 52

      Pages: 1787-1788

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Significance of three-demensional computed tomography a very old patients with sigmoid volvulus.2004

    • Author(s)
      Ebihara S, et al
    • Journal Title

      Geriatrics and Gerontology International 4

      Pages: 181-183

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Increased plasma 8-isoprostane levels in hypertensive subjects : the Tsurugaya project2004

    • Author(s)
      Hozawa A, Ebihara S, et al
    • Journal Title

      Hypertension Research 27

      Pages: 557-561

    • NAID

      10013604163

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A combinational therapy for pneumonia in elderly people.2004

    • Author(s)
      Kanda A, Ebihara S, et al.
    • Journal Title

      Journal of the American Geriatric Society 52

      Pages: 471-472

    • Related Report
      2004 Annual Research Report
  • [Publications] Ebihara S.et al.: "Impaired efficacy of cough in patients with Parkinsons disease"CHEST. 124. 1009-1015 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kanda A, Ebihara S.et al.: "A combinational therapy for pneumonia in the elderly people"Journal of the American Geriatric Society. (in press). (2004)

    • Related Report
      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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