The development of an innovative therapy for autoimmune diseases by controlling transcription factors in the regulatory T cells.
| Project/Area Number |
15591050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHIKATA Misaki The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (60219615)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHATA Kimito The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (70334406)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | regulatory T cells / transcription factors / autoimmune diseases / FOXP3 / SOCS3 / 転写因子 / 分化誘導 / cDNAクローニング / レトロウイルスベクター / トランスジェニックマウス / ホメオスタシス |
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| Research Abstract |
Cb4(+)CD25(+)regulatory T cells (Treg) contributes in homeostasis of the immune system by controlling an immune response. Recent accumulated findings suggest naturally occurring CD4(+)CD25(+)regulatory T cells which develop at least in the thymus via autoreactivity positive selection consists of an distinct T cell subset. As it is known that transcription factors contribute in the determination of cell lineage and transduction of the transcription factors induces cell differentiation. In order to find Treg-specific transcription factors, we generated Treg-specific expression cDNA library by subtraction. Among the library, we found two factors ; the one is (189), and the other is FOXP3. Foxp3 is demonstrated to play a pivotal role in Treg development. Therefore, we subsequently extended our research to screen FOXP3-assocaited molecules. By two yeast hybrid, we found SOCS3 is associated with FOXP3. The association involves SH2 region of SOCS3 and 81-210 amino acids region of FOXP3. Furthermore, We found that FOXP3 is associated the endogenous SOCS3 in FOXP3-transfected Treg cell clone. Considering the role of SOCS3 in the signal transduction, it is of interest to imagine that SOCS3 contribute in the immune regulation via Treg development.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Chondromodulin-I, a cartilage-derived angiogenesis inhibitory factor, suppresses T cell response ; an implication of a therapeutic potential for the treatment of arthritis.2004
Author(s)
Setoguchi K, Misaki Y, Kawahata K, Shimada, K Takuo J, Tanaka S, Oda H, Chisa Shukunami C, Nishizaki Y, Hiraki Y, Yamamoto K.
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Journal Title
Arthritis & Rheumatism. 50(3)
Pages: 828-839
Description
「研究成果報告書概要(欧文)」より
Related Report
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