Analysis of neural mechanism related to working memory based on multi-dipole estimation with high temporal resolution.

• Project/Area Number: 15591240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Metropolitan University of Health Sciences
• Principal Investigator: KIKUCHI Yoshiaki Tokyo Metropolitan University of Health Sciences, Faculty of Health Sciences, Professor, 保健科学部, 教授 (50134739)
• Project Period (FY): 2003 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥2,800,000 (Direct Cost: ¥2,800,000); Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: magnetoencephalography / mental rotation / spatio-temporal activity / working memory / multi-dipole estimation / MEG / 高時間分解能 / 複数電流双極子 / 運動前野 / 頭頂連合野

Research Abstract

There are many higher-order cognitive processes whose neural mechanisms are hard to study by using nonhuman primates. The mental rotation task is one of the best studied of these. We investigated the spatio-temporal brain activity underlying mental rotation of different kinds of stimuli by measuring the magnetoencephalogram of subjects performing two kinds of mental rotation tasks, based on multi-dipole estimation with high temporal resolution. Visual stimuli in one experiment consisted of hand shapes presented at various orientations, and those in the other consisted of a set of alphabetic characters and their mirror images presented at various orientations. All stimuli were presented in the left visual field. Activity associated with visual stimulus processing was estimated in the lateral occipital lobe, basal occipito-temporal area, and inferior temporal gyrus. Activities related to higher visual processing were differed between the two kinds of stimuli we used. For the hand shapes experiment, we found right inferior parietal lobule activity at 200-300 ms after the stimulus presentation. For the alphabetic characters, activity was found in the left superior temporal region at about 300 ms. Furthermore, activity related to mental stimulation in the inferior parietal lobule and premotor area were seen in the both experiments. In the experiments with hands, the premotor activity showed left-hemispheric dominance. However, in the experiments with alphabetic characters, the laterality of the premotor activity did not show left-hemispheric dominance. We inferred this difference was influenced by the subjects 'familiarity with the mental rotation of visual stimuli.

Research Products

• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: IEEE Transaction on Magnetics (to appear)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: Intermag 2005
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: Intermag 2005
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional obiects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y.et al.
  • Journal Title: IEEE Transaction on Magnetics (in print)
• [Journal Article] Spatio-temporal brain activity in mental rotation. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y.et al.
  • Journal Title: Neurology and Clinical Neurophysiology. (to be appeared)
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects. (2005)
  • Author(s): Kawamichi, H., Kikuchi, Y.et al.
  • Journal Title: Intermag 2005 (to be presented)
• [Journal Article] Language-related brain function during word repetition in post-stroke aphasics. (2004)
  • Author(s): Abo, M., Kikuchi, Y., et al.
  • Journal Title: NeuroReport 15 Pages: 1891-1894
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Spatio-temporal brain activity in mental rotation. (2004)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Neurology and Clinical Neurophysiology 66 Pages: 1-7
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Saptio-temporal activity in mental rotation of alphabetical character. (2004)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Proceedings of the 14^<th> International Conference on Biomagnetism Pages: 431-432
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Language-related brain function during word repetition in post-stroke aphasics (2004)
  • Author(s): Abo, M., Senoo, A., Watanabe, S., Miyano, S., Doseki, K., Sasaki, N, Kobayashi, K., Kikuchi, Y., Yonemoto, K.
  • Journal Title: Neuroreport 15 Pages: 1891-1894
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reorganization and Neuromudulation during word repetition in poststroke aphasics (2004)
  • Author(s): Abo, M., Senoo, A., Yonemoto, K., Watanabe, S., Kikuchi, Y., Miyano, S.
  • Journal Title: 14^<th> European Congress of Physical and Rehabilitation Medicine. Vienna, Austria, May 12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Traumatic brain injury rehabilitation in Japan: current and future challenges (2004)
  • Author(s): Watanabe, S., Yonemoto, K., Kikuchi, Y., Ohashi, M., Hashimoto, M., Abo, M., Miyano, M., Tanaka, M.
  • Journal Title: 14^<th> European Congress of Physical and Rehabilitation Medicine. Vienna, Austria, May 12-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Language-related brain function during word repetition in post-stroke aphasics. (2004)
  • Author(s): Abo, M., Kikuchi, Y., et al.
  • Journal Title: Neuroreport 15 Pages: 1891-1894
• [Journal Article] An fMRI study on neural activity for eyes and the resemblance. (2004)
  • Author(s): Tanaka, M., Kikuchi, Y., et al.
  • Journal Title: Proceedings of 14^<th> European Congress of Physical and Rehabilitation Medicine.
• [Journal Article] Saptio-temporal activity in mental rotation of alphabetical character. (2004)
  • Author(s): Kawamichi, H., Kikuchi, Y.et al.
  • Journal Title: Biomag 2004 (Edit by Halgren, E., Ahlfors, S., ) Pages: 431-432
• [Journal Article] Nonparametric regression analysis of functional brain images. (2003)
  • Author(s): Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.
  • Journal Title: Systems and Computers in Japan 35 Pages: 67-78
  • NAID: 110003184219
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Nonparametric regression analysis of functional brain images (2003)
  • Author(s): Tsukimoto, H., Kakimoto, M., Morita, C., Kikuchi, Y.
  • Journal Title: Systems and Computers in Japan Vol.35 Pages: 67-78
  • NAID: 110003184219
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal activity in mental rotation of alphabetical character (1994)
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Biomag 2004, (Edit by Halgren, E., Ahlfors, S.) Pages: 431-432
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Magnetoencephalographic measurement during two types of mental rotations of three-dimensional objects
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S.
  • Journal Title: IEEE Transaction on Magnetics (in print)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spatio-temporal brain activity in mental rotation
  • Author(s): Kawamichi, H., Kikuchi, Y., Ueno, S., Yoshizawa, S.
  • Journal Title: Neurology and Clinical Neurophysiology.
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] An fMRI study on neural activity for eyes and the resemblance
  • Author(s): Tanaka, M., Kikuchi, Y., Senoo, A., Sato, T., Mori, T., Watanabe, S., Abo, M., Yonemoto, K.
  • Journal Title: Proceedings of 14^<th> European Congress of Physical and Rehabilitation Medicine
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] 大渕, 乳井, 篠原, 菊池吉晃: "3次元MRIフーリエ変換法の画像再構成"第10回東京保健科学学会抄録集. 2. 10 (2003)
• [Publications] 宮本, 菊池吉晃, 妹尾, 田中: "立体図形の認知・記憶に関する脳内部位の検討"第10回東京保健科学学会抄録集. 12 (2003)
• [Publications] 田中, 菊池吉晃, 妹尾, 渡邉, 他: "眼の認知における主観評価と脳内活動との関係"第10回東京保健科学学会抄録集. 12 (2003)
• [Publications] 武藤, 菊池吉晃, 妹尾, 田中: "迷路探索に伴う脳内活動部位の検討"第10回東京保健科学学会抄録集. 12 (2003)
• [Publications] 岩山, 笠井, 伊藤, 菊池吉晃, 他: "外因性神経細胞分化誘導因子の開発"第10回東京保健科学学会抄録集. 2. 13 (2003)
• [Publications] Kawamichi, Y.Kikuchi, et al.: "Spatio-Temporal Brain Activity in Visual Mental Rotation Revealed by MEG"Biomag 2004. (to be presented). (2004)