| Project/Area Number |
15591287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
TOMIUCHI Seiji Kumamoto University, Graduate School of Medical Sciences, associate professor, 大学院・医学薬学研究部, 助教授 (20172182)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Akihiro Kumamoto University, Researchcenter for RedioIsotope sciences, associate professor, アイソトープ総合センター, 助教授 (20161903)
OGATA Ichirou Kumamoto University, Graduate School of Medical Sciences, assistant professor, 大学院・医学薬学研究部, 助手 (40343355)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | CT / SPECT combined system / Image fusiion / attenuation Correction / 211T1MyocardialSpect / 211TlMyocardialSpect / SPECT conbi system / Image fasion / attention corection / ^<211>Tl MYOCARDIAL SPECT |
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| Research Abstract |
Integrated SPECT/CT system which enables SPECT and CT imaging using a same bed is useful to make a fused image. We introduced gantry-free SPECT scanners(Skylight : ADAC) and 8-detector-row CT scanner(Lightspeed ultra : GE)(SPECT/CT combined system) in a same room and produce directly SPECT and CT imaging in 1 session without moving the patient. SPECT image can be fused with a high-resolution CT images using this system. CT images are also being used for attenuation correction in the reconstruction process of the SPECT emission data. The aim of this study was to evaluate the usefulness of CT-based attenuation correction for the Tl-201 myocardial SPECT using this system. We have also developed a method to integrate the information from 2 non-invasive cardiac imaging studies, myocardial perfusion SPECT and coronary CT angiography, and assessed the clinical application. Finally, we evaluated the clinical usefulness of the fused image in oncologic imaging.
We performed CT-based attenuation c
… More
orrection in 30 patients underwent Tl-201 myocardial SPECT. Increase in specificity in the right coronary arterial territory resulted in the improvement in uniformity of Tl-201 myocardial distribution.
Volume-rendering fused images were obtained from original coronary CT angiographic- and registered SPECT images using a volume-rendering fusion function in 10 patients with ischemic heart disease. 3D volume-rendering fused images clearly demonstrated the relationship of a relevant coronary artery and the abnormal perfusion territory in all patients. There was no clinically problematic misregistration between CT and SPECT images on the 3D volume-rendering fused images.
We assessed the usefulness of fused images of Tl-201 SPECT and CT images in the diagnosis of lymph node metastases of 36 patients with non-small cell lung cancer(NSCLC). Quantitative index of early images after attenuation correction was most useful to differentiate metastatic-from non-metastatic lymphnodes. This index was useful for the staging in patients with NSCLC.
Fused images are available in all SPECT studies using a software or integrated SPECT/CT scanners. However, further studies are necessary to obviate the clinical usefulness of fused images. Less
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