| Project/Area Number |
15591323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Akita University |
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Principal Investigator |
KATAYOSE Yoshihisa Akita University, School of medicine, research associate, 医学部, 助手 (40282165)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Jun-ichi Akita University, School of medicine, Professor, 医学部, 教授 (20112774)
MINAMIYA Yoshihiro Akita University, School of medicine, Associate professor, 医学部, 助教授 (30239321)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Breast cancer / sentinel lymph node / magnetite / magnetic sensor / breast conserving surgery |
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| Research Abstract |
We have developed a new type of the high-sensitivity portable magnetometer(MM), available for autoclave, using coiled alley and highly sensitive magnetic sensor for sentinel lymph node biopsy(SLNB). A diameter of the magnetic sensor is 3 cm that is thick for clinical usage.
We need to dissolve this problem to detect a sentinel lymph node easily. We have also developed the system, which was composed of a power supply and personal computer with display, to analyze a data form the magnetic sensor.
Forty nine breast cancer patients were enrolled to analyze a magnetic power after administration of magnetic fluid for SLNB. The identification rate of SN with MM were 98.0%(48/49). In our 49 series, 15 breast cancer patients had positive lymph node, and only one false negative case was found. The rate of accuracy, sensitivity, false negative, and specificity was 98.0, 93.3, 6.7, and 100%, respectively. We got the same results with gamma-probe method to identify the SN. We developed a novel method to detect SN using a magnetic fluid and a high-sensitivity portable magnetometer. This method appears to be as accurate and sensitive as SLN mapping using isotopes or blue dye; however, only a limited number of patients were investigated. Further investigation will thus be required to confirm the feasibility and safety of this approach.
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