Development of evaluation system for artificial organs from the viewpoints of clinical study, engineering, and statistics.
| Project/Area Number |
15591491
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | SHIBAURA INSTITUTE OF TECHNOLOGY |
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Principal Investigator |
FUJIMOTO Tetsuo SHIBAURA INSTITUTE OF TECHNOLOGY, DEPARTMENT OF ENGINEERING, PROFESSOR, 工学部, 教授 (50267473)
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| Co-Investigator(Kenkyū-buntansha) |
UMEZU Mitsuo WASEDA UNIVERSITY, GRADUATE SCHOOL OF SCIENCE AND ENGINEERING, PROFESSOR, 大学院・理工学研究科, 教授 (90132927)
OWASAKI Kiyotaka WASEDA UNIVERSITY, GRADUATE SCHOOL OF SCIENCE AND ENGINEERING, ASSISTANT PROFESSOR, 大学院・理工学研究科, 講師 (20339691)
KAWAZOE Kohei IWATE MEDICAL UNIVERSITY, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (50075561)
北村 信夫 京都府立医科大学, 心臓血管外科, 教授 (70075513)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2003: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | artificial organ / circulatory simulator / arterial prosthetic graft / artificial heart valve / ventricular assist system / medical database / medical statistics / hemodynamics |
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| Research Abstract |
A circulatory simulator was developed in order to evaluate artificial organs such as ventricular assist systems, artificial heart valves, and arterial prosthetic grafts from the view point of hemodynamics. Some experiments were conducted to demonstrate characteristics of a rotary pump used for a right ventricular assist system and a newly designed aortofemoral prosthetic Y graft in the simulator. As a result, it was revealed that there was definitely an incremental increase in the branch diameter increasing the flow rate through the graft. In this study, a newly designed pressure transducer and an expandable tube for clinical application were devised. The former is enough small to be fixed into artificial organs in which the pressure can be measured. The latter was designed to expand the diameter of the tube as a tracheal tube and a cannula for left ventricular bypass. These inventions are lodging patent applications. In addition, a new database system was developed in order to analyze clinical data statistically. Clinical data including pulse wave velocity (PWV) were analyzed actually by the system and it was revealed the tendency that the risk of the death increases accompanied by increase in PWV as a result. It is supposed that the combination of the simulator and the database system will be useful to evaluate artificial organs from the viewpoints of clinical study, engineering, and statistics.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Novel Cell Sheet Manipulator to Fabricate Three-Dimensional Tissue and to Quantify Cell Sheet Adhesiveness2004
Author(s)
Sato, K, Shimizu, T, Isoi, Y, Yamato, M, Kikuchi, A, Fujimoto, T, Okano, T
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Journal Title
Transactions of 7th World Biomaterials Congress - 2004 1849
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Book] 人工臓器で幸せですか?2005
Author(s)
梅津光生, 藤本哲男, 他
Total Pages
144
Publisher
コロナ社
Description
「研究成果報告書概要(和文)」より
Related Report
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