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Development of mice model of non-myeloablative stem cell transplantation for renal cell carcinoma and Its application

Research Project

Project/Area Number 15591711
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research Institutionlwate Medical University

Principal Investigator

FUJIOKA Tomaki  Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (80173409)

Co-Investigator(Kenkyū-buntansha) ISHIDA Yoji  Iwate Medical University, School of Medicine, Associated Professor, 医学部, 助教授 (70151389)
Project Period (FY) 2003 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
KeywordsRenal cell caricinoma / MUC-1 / HLA-A2 / Cytotoxic T lymphocyte / SCID mice / Non-myeloablative stem cell transplantation / 免疫療法 / 腫瘍ワクチン / 腫瘍特異ペプチド
Research Abstract

Development of mice model of non-myeloablative stem cell transplantation for renal cell carcinoma using human cell line
(A-498).
A-498 cell line, which derived from human renal cell carcinoma, expresses the MUC-1 peptide on HLA-A2.
(1) Establishment of HLA-A2 restricted MUC-1 peptide specific cytotoxic T lymphocytes (CT L).
Adherent cells from human mononuclear cells obtained from normal volunteer with HIA-A2 were cultured with rhGM(1SF, rhIL-4, and TNF-a. These cells were stimulated by MUG-i peptide several times during the culture to get the dendric cells. In addition, mononuclear cells with HIA-A2 were added to the dendric cells with the several stimulations by MUC-1 peptide. After 7 days incubation, CTLs, which is specific cytotoxic against A-498 cells, were established.
(2) A498 bearing SCID mouse
A-498 cells were injected to SCID mice subcutaneously. The survival durations of A-498 bearing SCID mice were investigated. The survival durations in 5 mice with 9.0x10^6 A498 were 52,58,90,90 and 90days. Those in mice with 3.5x10^7 A498 were 30, 34, 70, 90 and 90days. Therefore, mice with 5.0x10^7 were used in the next experiments.
(3) in vivo anti-tumor effect of CTLs administrations on A-498 bearing SCID mice.
CTLs (1x10^6) were injected into A-498(5.0x10^7) bearing 5(111) mice through the tail vain once a week The survival durations were compared between A-498 bearing mice with the injections of (Ills and lymphocytes.
A-498 bearing mice with the injections of CTLs survived 42 and 90 days, while those with lymphocytes did 25 and 63 days
These results revealed that (Ills administration prolonged the survival duration of A-498 bearing SCUD mice. A-498 bearing SCID mice with the administrations of MUG-1 specific CTLs provide the mice model of non-myeloablative stem cell transplantation for renal cell carcinoma.

Report

(3 results)
  • 2004 Annual Research Report   Final Research Report Summary
  • 2003 Annual Research Report
  • Research Products

    (63 results)

All 2004 2003 Other

All Journal Article (57 results) Publications (6 results)

  • [Journal Article] A case-control study of diet and prostate cancer in Japan : possible protective effect of traditional Japanese diet.2004

    • Author(s)
      Sonoda T et al.
    • Journal Title

      Cancer Sci 95(3)

      Pages: 238-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Comparisons of percent equol producers between prostate cancer patients and controls : Case-controlled studies of isoflavon in Japanese, Korean and American residents2004

    • Author(s)
      Akaza H et al.
    • Journal Title

      Jpn J Clin Oncol 34(2)

      Pages: 86-89

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hepatocyte growth factor and its receptor C-MET in acquired renal cystic disease associated with renal cell carcinoma2004

    • Author(s)
      Konda R et al.
    • Journal Title

      J.Urol 171

      Pages: 2166-2170

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Laparoscopic pyeloplasty for ureteropelvic junction obstruction : outcome of initial 12 procedures2004

    • Author(s)
      Iwamura M et al.
    • Journal Title

      Int J Urol 11

      Pages: 449-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer : genome-wide gene-expression profiles of prostate cancer and PINs2004

    • Author(s)
      Ashida S et al.
    • Journal Title

      Cancer Res 64(7)

      Pages: 5963-5972

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Subtype of BK virus prevalent in Japan and variation in their transcriptional control region.2004

    • Author(s)
      Takasaka T et al.
    • Journal Title

      J General Viorol 85

      Pages: 2821-2827

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] The 3^<rd> conference on Asian trends in prostate cancer hormone therapy2004

    • Author(s)
      Akaza H et al.
    • Journal Title

      Jpn J Cancer Chemother 31(8)

      Pages: 1283-1295

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Oncogenic role of NALP7 in testicular seminomas2004

    • Author(s)
      Okada K et al.
    • Journal Title

      Cancer Sci 95(12)

      Pages: 949-954

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Urinary Excretion of Vascular Endothelial Growth Factor is Increaser in Children with Reflux Nephropathy.2004

    • Author(s)
      Konda R et al.
    • Journal Title

      Nephron Clin Pract 98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Consensus primers for detecting monoclonal immunoglobulin heavy chain rearrangement in B-cell lymphomas.2004

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      J Clin Pathol 56(10)

      Pages: 778-779

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Short concensus probes with 3'-minor Groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas2004

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      Laboratory Investigation 84

      Pages: 932-936

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Uncommon karyotypic abnormality of t(11;19)(q23;p13.3) in a patient with blastic phase of chronic myeloid leulemia2004

    • Author(s)
      Keijiro S et al.
    • Journal Title

      Cancer Genetics & Cytogenetics 150

      Pages: 159-163

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and biological significance of CD56 antigen expression in acute promyelocin leukemia.2004

    • Author(s)
      Ito S et al.
    • Journal Title

      Leuk Lymphoma 45(9)

      Pages: 1783-1789

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful Treatment with Cyclosporine and High-Dose Gamma Immunoglobulin for Persistent Paravovirus B19 Infection in a Patient with Refractory Autoimmune Hemolytic Anemia2004

    • Author(s)
      Ito S et al.
    • Journal Title

      International Journal of Hematology 80

      Pages: 250-253

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] A case-control study of diet and prostate cancer in Japan : possible protective effect of traditional Japanese diet.2004

    • Author(s)
      Sonoda T, Fujoka T. et al.
    • Journal Title

      Cancer Sci 95(3)

      Pages: 238-242

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Comparisons of percent equol producers between prostate cancer patients and controls Case-controlled studies of isoflavon in Japanese, Korean and American residents.2004

    • Author(s)
      Akaza H, Fujoka T. et al.
    • Journal Title

      Jpn I Chin Oncol 34(2)

      Pages: 86-89

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Expression of hepatocyte growth factor and its receptor C-MET in acquired renal cystic disease associated with renal cell carcinoma.2004

    • Author(s)
      Konda R, Fujoka T. et al.
    • Journal Title

      J. Urol 171

      Pages: 2166-2170

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Laparoscopic pyeloplasty for ureteropelvic junction obstruction : outcome of initial 12 procedures.2004

    • Author(s)
      Iwamura M, Fujoka T. et al.
    • Journal Title

      Int J Urol 11

      Pages: 449-455

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs.2004

    • Author(s)
      Ashida 5, Fujoka T. et al.
    • Journal Title

      Cancer Res 64(7)

      Pages: 5963-5972

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Subtype of BK virus prevalent in Japan and variation in their transcriptional control region.2004

    • Author(s)
      Takasaka T, Fujoka T. et al.
    • Journal Title

      J General Viorol 85

      Pages: 2821-2827

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] The 3^<rd> conference on Asian trends in prostate cancer hormone therapy.2004

    • Author(s)
      Akaza H, Fujoka T. et al.
    • Journal Title

      Jpn J Cancer Chemother 31(8)

      Pages: 1283-1295

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Oncogenic role of NALP7 in testicular seminomas.2004

    • Author(s)
      Okada K, Fujoka T. et al.
    • Journal Title

      Cancer Sci 95(12)

      Pages: 949-954

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Urinary Excretion of Vascular Endothelial Growth Factor Is Increased in Children with Reflux Nephropathy.2004

    • Author(s)
      Konda R, Fujoka T. et al.
    • Journal Title

      Nephron Clin Pract 98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Consensus primers for detecting monoclonal jmmunoglobulin heavy chain rearrangement in B-cell lymphomas.2004

    • Author(s)
      Uchiyama M, Ishida Y. et al.
    • Journal Title

      J Gun Pathol 56(10)

      Pages: 778-779

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Short concensus probes with 3'-minor Groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas.2004

    • Author(s)
      Uchiyama M, Isida Y. et al.
    • Journal Title

      Laboratory lnvestigatiorn 84

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Uncommon karyotypic abnormality of t(11;19)(q23;p13.3) in a patient with blastic phase of chronic myeloid leulemia: Case report.2004

    • Author(s)
      Keijiro Suzuki, Yoji, Ishida et al.
    • Journal Title

      Cancer Genetics & Cytogenetics 150

      Pages: 159-163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Clinical and biological significance of CD56 antigen expression in acute promyelocyti leukemia.2004

    • Author(s)
      Ito S, Ishida Y. et al.
    • Journal Title

      Leuk Lymphoma. 45(9)

      Pages: 1783-11

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Successful Treatment with Cyclosporine and High-Dose Gamma Immunoglobulin for Persistent Paravovirus B19 Infection in a Patient with Refractory Autoimmune Hemolytic Anemia.2004

    • Author(s)
      Ito S, Ishida Y. et al.
    • Journal Title

      International Journal of Hematology 80

      Pages: 250-253

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer : genome-wide gene-expression profiles of prostate cancers and PINs2004

    • Author(s)
      Ashida S et al.
    • Journal Title

      Cancer Res 64(7)

      Pages: 5963-5972

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Comparisons of percent equol producers between prostate cancer patients and controls :Case-controlled studies of isoflavon in Japanese, Korean and American residents2004

    • Author(s)
      Akaza H et al.
    • Journal Title

      Jpn J Clin Oncol 34(2)

      Pages: 86-89

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Urinary Excretion of Vascular Endothelial Growth Factor Is Increased in Children with Reflux Nephropathy.2004

    • Author(s)
      Konda R et al.
    • Journal Title

      Nephron Clin Pract 98

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Short consensus probes with 3'-minor Groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas2004

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      Laboratory Investigation 84

      Pages: 932-936

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Uncommon karyotypic abnormality of t(11;19)(q23;p133) in a patient with blastic phase of chronic myeloid leulemia2004

    • Author(s)
      Keijiro S et al.
    • Journal Title

      Cancer Genetics & Cytogenetics 150

      Pages: 159-163

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Clinical and biological significance of CD56 antigen expression in acute promyelocyti leukemia.2004

    • Author(s)
      Ito S et al.
    • Journal Title

      Leuk Lymphoma 45(9)

      Pages: 1783-1789

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunogloblin A nephrophathy (IgAN) in Japanese patients.2003

    • Author(s)
      Obara W et al.
    • Journal Title

      J Hum Genet 48

      Pages: 293-299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of solute carrier family 12(sodium/choloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphism.2003

    • Author(s)
      Tanaka N et al.
    • Journal Title

      Diabetes 52(11)

      Pages: 2848-2853

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray.2003

    • Author(s)
      Okada K et al.
    • Journal Title

      Int J Oncol 23

      Pages: 1615-1635

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Higher consumptiopn of green tea may enhance equol production.2003

    • Author(s)
      Miyanaga N et al.
    • Journal Title

      Asian Pac J Cancer Prev 4

      Pages: 297-301

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative polymerase chain reaction.2003

    • Author(s)
      Yashima A et al.
    • Journal Title

      Leuk Res 27

      Pages: 925-934

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Transfusion-related problems following major ABO-incompatible bone marrow transplantation2003

    • Author(s)
      Tasaki T et al.
    • Journal Title

      Transfusion and Apheresis Science 28

      Pages: 155-161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Consensus primers for detecting monoclonal immunoglobulin heavy chain rearrangement in B-cell lymphomas2003

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      J Clin Pathol 56(10)

      Pages: 778-779

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Development of immunoglobulin variable heavy-chain gene consensus probes with conjugated 3'-minor groove binder groups for monitoring minimal residual disease in childhood acute lymphoblastic leukemia.2003

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      Cancer Sci 92

      Pages: 877-885

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas2003

    • Author(s)
      Uchiyama M et al.
    • Journal Title

      J Clin Pathol 56(12)

      Pages: 952-955

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Characteristics of Japanese Thalassemia2003

    • Author(s)
      Hattori Y et al.
    • Journal Title

      Int J Human Genet 3(4)

      Pages: 259-267

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2004 Annual Research Report 2004 Final Research Report Summary
  • [Journal Article] Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunogloblin A nephropathy (IgAN) in Japanese patients2003

    • Author(s)
      Obara W, Fujioka T. et al.
    • Journal Title

      J Hum Genet 48

      Pages: 293-299

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of solute carrier family 12(sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphism.2003

    • Author(s)
      Tanaka N, Fujioka T. et al.
    • Journal Title

      Diabetes 52(11)

      Pages: 2848-2853

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray.2003

    • Author(s)
      Okada K, Fujioka T. et al.
    • Journal Title

      Int J Oncol 23

      Pages: 1615-1635

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Higher consumptiopn of green tea may enhance equol production.2003

    • Author(s)
      Miyanaga N, Fujioka T. et al.
    • Journal Title

      Asian Pac J Cancer Prey 4

      Pages: 297-301

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative polymerase chain reaction.2003

    • Author(s)
      Yashima A, Ishida Y et al.
    • Journal Title

      Leuk Res. 27

      Pages: 925-934

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Transfusion-related problems following major ABO-incompatible bone marrow transplantation2003

    • Author(s)
      Tasaki Tetsunori, Ishida Yoji, et al.
    • Journal Title

      Transfusion and Apheresis Science 28

      Pages: 155-161

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Consensus primers for detecting monoclonal immunoglobulin heavy chain rearrangement in B-cell lymphomas.2003

    • Author(s)
      Uchiyama M, Ishida Y. et al.
    • Journal Title

      J Clin Pathol 56(10)

      Pages: 778-779

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Development of immunoglobulin variable heavy-chain gene consensus probes with conjugated 3'-minor groove binder groups for monitoring minimal residual disease in childhood acute lymphoblastic leukemia.2003

    • Author(s)
      Uchiyama M, Ishida Y. et al.
    • Journal Title

      J Clin Pathol 56(12)

      Pages: 952-955

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas.2003

    • Author(s)
      Uchiyama M, Ishida Y. et al.
    • Journal Title

      Cancer Sci 92

      Pages: 877-885

    • NAID

      10012438480

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Characteristics of Japanese Thalassemia2003

    • Author(s)
      Hattori Y, Ishida Y. et al.
    • Journal Title

      Int J Human Genet 3(4)

      Pages: 259-267

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2004 Final Research Report Summary
  • [Journal Article] Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunogloblin A nephropathy (IgAN) in Japanese patients.2003

    • Author(s)
      Obara W et al.
    • Journal Title

      J Hum Genet 48

      Pages: 293-299

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Association of solute carrier family 12(sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analyses of single nucleotide polymorphism.2003

    • Author(s)
      Tanaka N et al.
    • Journal Title

      Diabetes 52(11)

      Pages: 2848-2853

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Transfusion-related problems following major ABO-incompatible bone marrow trasplantation2003

    • Author(s)
      Tasaki T et al.
    • Journal Title

      Transfusion and Apheresis Science 28

      Pages: 155-161

    • Related Report
      2004 Annual Research Report
  • [Publications] Okada K, Katagiri T, Tsunoda T, Mizutani Y, Suzuki Y, Kamada M, Shuin T, Miki T, Nakamura Y.: "Analysis of gene-expression profiles in testicular seminomas using a genome-wide cDNA microarray."International Journal of Oncology. 23. 1615-1635 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka N, Babazono T, Saito S, Sekine A, Tsunoda T, Haneda Y, Fujioka T, Kaku K, Kawamori R, Kikkawa R, Iwamoto Y, Nakamura Y, Maeda S.: "Association of solute carrier family 12 (sodium/chloride) member 3 with diabetic nephropathy, identified by genome-wide analysis of single nucleotide polymorphism."Diabetes. 52(11). 2848-2853 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yashima A, Maesawa C, Uchiyama M, Tarusawa M, Satoh T, Satoh M, Enomoto S, Sugawara K, Numaoka H, Murai K, Utsugisawa T, Ishida Y, Masuda T.: "Quantitative assessment of contaminating tumor cells in autologous peripheral blood stem cells of B-cell non-Hodgkin lymphomas using immunoglobulin heavy chain gene allele-specific oligonucleotide real-time quantitative-polymerase chain reaction."Leuk Res.. 27. 925-934 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tasaki Tetunori, Satoh Shyukuko, Gotoh Kenji, Fujii Keiko, Sasaki Sakiko, Takadate Junko, Tachibana Mihoko, Ono Yoko, Ishida Yoji.: "Transfusion-related problems following major ABO-incompatible bone marrow transplantation"Transfusion and Apheresis Science. 28. 155-161 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uchiyama M, Maesawa C, Yashima A, Tarusawa M, Satoh S, Ishida Y, Ito S, Murai K, Enomoto S, Utsugisawa T, Motoyoshi K, Masuda T.: "Development of consensus fluorogenically labeled probes of the immunoglobulin heavy-chain gene for detecting minimal residual disease in B-cell non-Hodgkin lymphomas"Cancer Sci.. 92. 877-885 (2003)

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      2003 Annual Research Report
  • [Publications] Hattori Y, Yamashiro Y, Okayama N, Tanaka K, Yamauchi H, Ishida Y, Kuriya S.: "Characteristics of Japanese Thalassemia"Int.J.Human Genet.. 3(4). 259-267 (2003)

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      2003 Annual Research Report

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Published: 2003-04-01   Modified: 2016-04-21  

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