Strategy of gene therapy against ovarian cancer by using endostatin
| Project/Area Number |
15591784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
YONEYAMA Koichi Nippon Medical School, Dept.of Ob/Gy, Associate Professor, 医学部, 講師 (90220772)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSE Keisuke Nippon Medical School, Dept.of Ob/Gy, instructor, 医学部, 助手 (30373012)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2004: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2003: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | ovarian cancer / endostatin / VEGF / angiogenesis / 血管新生抑制因子 |
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| Research Abstract |
In this study, we investigated the serum endostatin and VEGF(vascular endothelial growth factor) levels of the patients with various ovarian tumors. [MATERIALS AND METHODS]To evaluate the serum levels of endostatain, blood samples were obtained from the fourteen patients with ovarian cancers, four normal volunteers. And to evaluate the serum levels of VEGF, blood samples were obtained from the twenty four patients with ovarian cancers, twenty three patients with benign ovarian tumors and nine normal volunteers. Informed concents were obtained by all pearsons. [RESULTS]The serum endostatin level was 94.9±36.4 ng/mL in the patients with ovarian cancers, 63.01±17.1ng/mL in the normal volunteers. The serum VEGF level was 664.3 pg/mL in the patients with ovarian cancers, 307.4 pg/mL in the patients with benign ovarian tumors, 311.2 pg/mLn the normal volunteers. The serum endostatin and VEGF levels in the patients with ovarian cancers were clearly higher than normal volunteers (p<0.05). [CONCLUSIONS]The serum endostatin and VEGF levels can be useful marker for the ovarian cancer screening.
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Report
(3 results)
Research Products
(17 results)
