Functional MRI during electrical auditory stimulation as an objective evaluation of the retrocochlear auditory pathway in profoundly deaf patients
| Project/Area Number |
15591822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Miyazaki (2005)
University of the Ryukyus (2003-2004) |
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Principal Investigator |
TONO Tetsuya University of Miyazaki, faculty of Medicine, Department of Otorhinolaryngology, Professor, 医学部, 教授 (80145424)
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| Co-Investigator(Kenkyū-buntansha) |
USHISAKO Yasuaki University of Miyazaki, faculty of Medicine, Department of Otorhinolaryngology, Associate, 医学部, 助手 (10185001)
GANAHA Akira University of Miyazaki, faculty of Medicine, Department of Otorhinolaryngology, Associate, 医学部, 助手 (00347155)
KOMADA Takao University of Miyazaki, faculty of Medicine, Department of Otorhinolaryngology, Associate Professor, 医学部, 助教授 (40153564)
赤嶺 珠 琉球大学, 医学部, 助手 (50325841)
吉長 正富 琉球大学, 医学部附属病院, 助手 (10325855)
大輪 達仁 琉球大学, 医学部, 助手 (60284981)
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| Project Period (FY) |
2003 – 2005
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| Project Status |
Completed (Fiscal Year 2005)
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| Budget Amount *help |
¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | cochlear implant / profound deafness / retrocochlear auditory pathway / electrical promontory stimulation / functional MRI / auditory cortex / 電気的聴覚刺激 / Electroaudiometer / カーボン電極 / 一次聴覚野 / 蝸牛電気刺激検査装置 |
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| Research Abstract |
Electrical promontory stimulation test has been used for preoperative functional evaluation of the retrocochlear auditory pathway in cochlear implant candidates. However, due to the lack of an objective information on cortical integration, results of this test do not seem to predict what extent the cochlear implant will be successful.
In order to employ functional magnetic resonance imaging (fMRI) to assess the cortical activation during electrical auditory stimulation, safe stimulation devices allowing to use inside the gauss field of an MR system was developed. We performed fMRI by using these electrical stimulation devices in 4 deaf adult patients before cochlear implantation. All 4 patients showed activation of the auditory cortex and good postoperative performance with a cochlear implant. Demonstration of the cortical activation in one patient with mitochondrial diseases also helped to encourage both patients and surgeons for cochlear implantation.
This method can thus provide an objective test of the integrity of the retrocochlear auditory pathway and help the surgeon in decision making before cochlear implantation.
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Report
(4 results)
Research Products
(13 results)
