Pathogenesis of polypoidal choroidal vasculopathy focusing on the peculiarity of chorotial vessels
| Project/Area Number |
15591866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
OKUBO Akiko Kagoshima University, University Hospital, Faculty of Medicine and Dentistry, Assistant professor, 医学部・歯学部附属病院, 講師 (60295251)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Taiji Kagoshima University, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (10235179)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2004: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2003: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | polypoidal choroidal vasculopathy / choroidal vessel / age-related macular degeneration / pathogenesis / treatment |
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| Research Abstract |
[Background and Purpose]
Polypoidal choroidal vasculopathy(PCV) is characterized by branching choroidal vessels with polyp-like terminal aneurismal dilations. Clinically, the vascular abnormality appears to be in the inner choroid and is composed of 2 basic elements : a polypoidal vessel and a branching vascular network. Although PCV is known to have a predilection for Asian populations, the exact pathology of it remains unclear and there are no current treatment guidelines. In this study, we aimed to evaluate choroidal vasculature and find efficient treatments for patients win PCV.
[Results]
1.Choroidal vessels in PCV
(1)Branching vascular network
We reported that in PCV the choroidal vasculature is altered with time, in that some vessels in the inner choroid and even the choriocapillaris may close and collateral vessels and/or new vessels may develop to form the branching vascular network. (Graefe's Archive for Clinical and Experimental Ophthalmology, 242:962-5,2004)
(2)Pulsatile blood flow
We reviewed our series of cases of PCV with pulsatile polypoidal vessels and evaluated the features of such vessels in PCV. It is a unique and important characteristic that has not been reported with any other chorio-retinal diseases. (Ophthalmology, in press)
2.Effect of Injection of triamcinolone acetonide(TA) for exudative age related macular degeneration/PCV
We evaluated the effect of intravitreal/sub-Tenon TA with exudative age related macular degeneration(AMD)/PCV. Intravitreal TA provided short-term improvement in visual acuity and fundus findings in exudative AMD without significant side effects such as intraocular pressure increase and endophthalmitis. (Ophthalmologica, in press)
Trans-Tenon's retrobulbar TA injection may be a potential option for treating PCV from the point of view of effectiveness, safety, and cost. (Graefe's Archive for Clinical and Experimental Ophthalmology, in press)
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Report
(3 results)
Research Products
(13 results)
