| Project/Area Number |
15592119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Oita University (2004)
大分医科大学 (2003) |
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Principal Investigator |
MATSUMOTO Yushi Oita University, Faculty of Medicine, Department of Oncological Science, Assistant Professor, 医学部, 講師 (10239121)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Shigetaka Oita University, Faculty of Medicine, Department of Oncological Science, Professor, 医学部, 教授 (90053222)
KAWANO Kenji Oita University, Faculty of Medicine, Department of Oncological Science, Associate Professor, 医学部, 助教授 (50214664)
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| Project Period (FY) |
2003 – 2004
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| Project Status |
Completed (Fiscal Year 2004)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Keywords | oral cancer / lymphatics / lymphangiogenesis / histochemistry / blood vessels |
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| Research Abstract |
Lymphangiogenesis and it's networks in oral cancer play an important role in the metastasis of malignant cells. The present histochemical study was designed to investigate the regeneration of lymphatic vessels in the dorsal skin of the rat. The lymphatic vessels were examined by enzyme-histochemistry and immunohistochemistry. The lymph-angiogenic vessels extending from the stump revealed dynamic structural changes, including highly elongated cytoplasm and filopodium-like endothelial projections at their leading tip, suggesting a high migratory potential to produce a new vascular channel. Vascular sprouting of preexisting lymphatics essentially contributed to the lymphatic regeneration.
Lymphangiogenesis in the implant progressively advanced throughout the experimental period. The present findings suggest that the implantation of a collagen sheet in injured skin affords fine structural and functional repair via the regeneration of the microcirculation, including the lymphatic system. This procedure provides a useful model for the investigation of cutaneous lymphangiogenesis.
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