| Co-Investigator(Kenkyū-buntansha) |
TAKATA Yutaka Kyushu Dental College, Dentistry, Professor, 歯学部, 教授 (40163208)
YOKOTA Makoto Kyushu Dental College, Dentistry, Professor, 歯学部, 教授 (40107298)
NAITO Toru Fukuoka Dental College, Dentistry, lecturer, 歯学部, 講師 (10244782)
MURAOKA Kousuke Kyushu Dental College, Dentistry, Assistant, 歯学部, 助手 (80382422)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2004: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
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| Research Abstract |
To investigate the relationship between the periodontal disease and cerebral apoplexy by a prospective intervention examination, we did periodontal disease evaluation and carotid artery ultrasonography, brain MRI, fasting blood examination, and history taking, and then started a periodontal therapy in 2003.
In 2004 and 2005, we performed all these examinations as a reevaluation after a periodontal therapy again. From 2003 to 2004, total 16 patients were enrolled, and then four patients dropped out. We analyzed 12 patients' data of 3 points from 2003 to 2005 by Friedman test.
The number of the survival teeth decreased from 21.7 to 20.2 significantly. After one year, number of sites where the pocket depth (PD) was more than 6mm or 4mm, bleeding on probing (BOP), decreased significantly, and were preserved afterwards.
In fasting blood examination, white blood cell count decreased, Hb increased, and-γGTP improved. Maximal intima-media thickness (IMT) of right common carotid artery measured by ultrasonography, were related with number of sites of PD≧4mm, white blood cell count, red blood cell count, Hb, fasting blood glucose and HbA1c by single regression analysis. By multiple regression analysis of these factors, only HbA1c remained. In brain MRI, five people already accepted an atherosclerotic change at 2003, but one of them improved it one year later and did not change afterwards (improvement group). Four remainders were constant for two years (constant group). An atherosclerotic change appeared to two patients newly one year later and did not change afterwards (aggravation group). Since periodontal therapy was effective in both of improvement group and aggravation group, there seems to be not any relation between a change of brain MRI and periodontal therapy.
As a result, we were not able to find the apparent influence of a periodontal therapy on a change of cerebral examinations.
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